Natural-Product-Inspired Discovery of Trimethoxyphenyl-1,2,4-triazolosulfonamides as Potent Tubulin Polymerization Inhibitors.
1,2,4-Triazoles
Antitumor agents
Cell-cycle arrest
Natural products
Tubulin polymerization inhibitors
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
revised:
10
11
2023
received:
18
10
2023
pubmed:
17
11
2023
medline:
17
11
2023
entrez:
17
11
2023
Statut:
aheadofprint
Résumé
An approach of natural product-inspired strategy and incorporation of an NP-privileged motif has been investigated for the discovery of new tubulin polymerization inhibitors. Two series, N-Arylsulfonyl-3-arylamino-5-amino-1,2,4-triazole derivatives, and their isomers were considered. The compounds were synthesized by construction of the N-aryl-1,2,4-triazole-3,5-diamine motif and sulfonylation. Although the chemo- and regioselectivity in sulfonylation were challenging due to multiple ring-tautomerizable-NH and exocyclic NH
Identifiants
pubmed: 37975190
doi: 10.1002/cmdc.202300562
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300562Subventions
Organisme : DST-SERB
ID : SERB-CRG/2020/000256
Organisme : CSIR
ID : CSIR-02/(0441)/21/EMR-II
Organisme : Government of India
ID : JCB/2019/000016
Organisme : Department of Science and Technology
Organisme : NIPER
Informations de copyright
© 2023 Wiley-VCH GmbH.
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