[Microtubular network and functionality of the striated skeletal muscle].
Réseau microtubulaire et fonctionnalité du muscle strié squelettique.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
medline:
20
11
2023
pubmed:
17
11
2023
entrez:
17
11
2023
Statut:
ppublish
Résumé
Striated skeletal muscles are made of post-mitotic and multinucleated cells: muscle fibers, in which nuclei are regularly spaced and positioned at their periphery. The specific positioning of nuclei, necessary for the proper functioning of the muscle, is mainly regulated by the microtubule network and partner proteins. Many muscular pathologies present alterations in both the organization of the microtubule network and nuclear positioning, as observed in Duchenne Muscular Dystrophy, centronuclear myopathies or various neuromuscular diseases. The importance of the microtubule interactome and its influence in the maintenance of skeletal muscle homeostasis is a key issue in understanding muscle diseases. Réseau microtubulaire et fonctionnalité du muscle strié squelettique. Les muscles striés squelettiques sont constitués de cellules post-mitotiques et multinucléées : les fibres musculaires, dans lesquelles les noyaux sont régulièrement espacés et positionnés à leur périphérie. Ce positionnement spécifique des noyaux, nécessaire au bon fonctionnement du muscle, est essentiellement régulé par le réseau microtubulaire et ses partenaires protéiques. De nombreuses pathologies musculaires présentent une altération à la fois de l’organisation du réseau microtubulaire et du positionnement nucléaire, comme observé dans la Dystrophie Musculaire de Duchenne, les myopathies centronucléaires ou certaines maladies neuromusculaires. L’importance de l’interactome microtubulaire et son influence dans le maintien de l’homéostasie du muscle strié squelettique est un enjeu capital dans la compréhension des pathologies musculaires.
Autres résumés
Type: Publisher
(fre)
Réseau microtubulaire et fonctionnalité du muscle strié squelettique.
Identifiants
pubmed: 37975771
doi: 10.1051/medsci/2023146
pii: medsci230146s
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
54-57Informations de copyright
© 2023 médecine/sciences – Inserm.
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