Allogenic Umbilical Cord Tissue for Rotator Cuff Injuries.
Journal
Sports medicine and arthroscopy review
ISSN: 1538-1951
Titre abrégé: Sports Med Arthrosc Rev
Pays: United States
ID NLM: 9315689
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
medline:
20
11
2023
pubmed:
17
11
2023
entrez:
17
11
2023
Statut:
ppublish
Résumé
Highly prone to injury, the rotator cuff greatly contributes to the stability and mobility of the shoulder. Clinicians prioritize conservative treatment, resorting to surgery only when necessary, although they are hindered by inherent limitations. Biological therapies, including perinatal tissue, such as umbilical cord (UC) tissue, hold promise for treating rotator cuff injuries (RCIs) in the field of regenerative medicine. This article qualitatively presents the in vitro, preclinical, clinical, and ongoing scientific literature exploring the application of UC tissue and associated mesenchymal stem cells in the context of RCIs. Employing the "Preferred Reporting Items for Systematic Reviews and Meta-analyses" guidelines, a systematic review was conducted. These studies have presented substantial evidence indicating that UC tissue and UC-derived mesenchymal stem cells are safe and potentially efficacious for managing RCIs, though more adequately powered randomized controlled trials are warranted to further establish efficacy and justify clinical use.
Identifiants
pubmed: 37976128
doi: 10.1097/JSA.0000000000000369
pii: 00132585-202309000-00004
doi:
Types de publication
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-79Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure: A.G. is a consultant for BioIntegrate Inc. The remaining authors declare no conflict of interest.
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