SCGN and STAT3 expressions are associated with the prognosis of ccRCC.
Clear cell renal cell carcinoma (ccRCC) STAT3 SCGN PDL1 immunohistochemistry
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
12
09
2023
revised:
16
10
2023
accepted:
09
11
2023
medline:
29
11
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
ppublish
Résumé
Clear cell renal cell carcinoma (ccRCC) is highly heterogeneous and accounts for about 70% of RCC. Its prognosis is worse than that of most histological types of RCC. In order to find potential biomarkers that may influence the prognosis and survival in ccRCC patients, we explored the expressions of STAT3, PDL1 and SCGN (secretagogin) in ccRCC based on the data of TCGA (n = 529), EMATAB-1980 (n = 99) and our own cohort (n = 99). Our study demonstrated that ccRCC patients with low STAT3 expression and high SCGN expression might have a better prognosis. No significant difference in the positive rate of SCGN expression was found when comparing the primary lesion with the matched metastatic liver lesions. The percentage of high SCGN expression in the primary lesion of metastatic ccRCC patients was significantly lower than that of patients with only the renal lesion. In view of the conclusion that STAT3 high expression cases are resistant to sunitinib, STAT3 immunohistochemistry results are essential for designing non-operative treatments. SCGN has the potential to become an indicator for subtype classification of ccRCC.
Identifiants
pubmed: 37977033
pii: S0344-0338(23)00641-6
doi: 10.1016/j.prp.2023.154940
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
STAT3 protein, human
0
STAT3 Transcription Factor
0
SCGN protein, human
0
Secretagogins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
154940Informations de copyright
Copyright © 2023 Elsevier GmbH. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest No.