Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films.
Mass spectrometry imaging
Pharmaceuticals
Poly(ester urea)
Polymer thin films
Surface layer analysis
Journal
Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
15
05
2023
revised:
17
09
2023
accepted:
25
10
2023
pmc-release:
01
12
2024
medline:
20
11
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
ppublish
Résumé
Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release over time. Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-MALDI-MSI) is a unique analytical technique that provides an optical representation of chemical compositions that exist at the surface of polymeric materials. Solvent-free sublimation is employed for application of matrix to the sample surface, so that only molecules in direct contact with the matrix layer are detected. Here, these methodologies are utilized to visualize variations in drug concentration at both the air and substrate interface in pharmaceutical-loaded polymer films.
Identifiants
pubmed: 37977787
pii: S0003-2670(23)01184-4
doi: 10.1016/j.aca.2023.341963
pmc: PMC10657383
mid: NIHMS1943966
pii:
doi:
Substances chimiques
Pharmaceutical Preparations
0
Urea
8W8T17847W
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
341963Subventions
Organisme : NIGMS NIH HHS
ID : R44 GM140795
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Rapid Commun Mass Spectrom. 2011 Oct 15;25(19):2809-14
pubmed: 21913259
JBJS Rev. 2017 Aug;5(8):e5
pubmed: 28796696
ACS Macro Lett. 2012 Aug 21;1(8):1024-1027
pubmed: 35607030
Anal Chem. 2006 Sep 15;78(18):6448-56
pubmed: 16970320
J Proteome Res. 2020 Sep 4;19(9):3620-3630
pubmed: 32786684
J Am Soc Mass Spectrom. 2007 Sep;18(9):1646-52
pubmed: 17659880
Chem Rev. 2013 Apr 10;113(4):2309-42
pubmed: 23394164
Eur J Pain. 2007 Jul;11(5):490-518
pubmed: 17070082
Mass Spectrom Rev. 2023 Apr 18;:
pubmed: 37070280
Top Curr Chem. 2013;331:1-36
pubmed: 22371170
Rapid Commun Mass Spectrom. 2005;19(2):255-60
pubmed: 15609365
ACS Macro Lett. 2018 Jul 17;7(7):795-800
pubmed: 35650770
Anal Chem. 2018 Nov 20;90(22):13427-13433
pubmed: 30346135
Annu Rev Chem Biomol Eng. 2010;1:149-73
pubmed: 22432577
Analyst. 2013 Aug 7;138(15):4215-28
pubmed: 23658933
Molecules. 2018 Mar 17;23(3):
pubmed: 29562618
Int J Mol Med. 2007 Aug;20(2):155-9
pubmed: 17611632
Anal Chem. 2013 May 21;85(10):4998-5004
pubmed: 23594377
ACS Macro Lett. 2018 Apr 17;7(4):487-492
pubmed: 35619347
Ann Surg. 2018 Jun;267(6):1056-1062
pubmed: 29215370
Eur Phys J E Soft Matter. 2017 Oct;40(10):85
pubmed: 28983828
Anal Bioanal Chem. 2011 Jul;401(1):127-34
pubmed: 21336787
Rapid Commun Mass Spectrom. 2001;15(15):1364-73
pubmed: 11466797
Biomaterials. 2018 Nov;182:44-57
pubmed: 30103171
J Vac Sci Technol A. 2020 Dec;38(6):063208
pubmed: 33281279
J Am Soc Mass Spectrom. 2010 Feb;21(2):220-31
pubmed: 19910210
Annu Rev Phys Chem. 2021 Apr 20;72:307-329
pubmed: 33441032
Anal Chem. 2016 Feb 16;88(4):2392-8
pubmed: 26814665
J Control Release. 2021 Jan 10;329:316-327
pubmed: 33278481
J Am Soc Mass Spectrom. 2005 Jan;16(1):90-3
pubmed: 15653367