A gastric sarcoma from 3000 years ago: paleopathological diagnosis at the field.
Ancient Egypt
Egyptian mummies
Gastric sarcoma
Histological analysis
Neoplasia
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
16
10
2023
accepted:
23
10
2023
medline:
18
11
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
aheadofprint
Résumé
Ancient remains tell a lot to those who can solve their mysteries. Mummified remains of individuals have the potential to tell their life stories. Pathological conditions in mummies are identified, commonly, thorough macroscopic inspection and radiological techniques. In 2017, a hypogeum tomb was excavated close to the courtyard of Djehuty's tomb (TT11) at the archaeological site of the Spanish Djehuty Project in Luxor (Egypt). In Sector 10, a set of at least 10 mummies were recovered. All showed clear signs of plundering and were found scattered at the site. Wrappings and associated goods indicated that the individuals were from the first half of the 20 All the individuals were male and from a high social status. Upon removing the individuals for study, two dried stomachs were found. There were clear macroscopic differences. A field histological analysis was performed which revealed that the stomach that showed no alterations, at first glance, presented a pathological pattern that was compatible with gastric sarcoma. Malignant diseases are seldom described in Paleopathology; to our knowledge, this is the oldest and most unique case of this type of pathology in mummies worldwide.
Identifiants
pubmed: 37978144
doi: 10.1007/s12094-023-03341-z
pii: 10.1007/s12094-023-03341-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).
Références
Esper JF. Ausführliche Nachricht von neuentdeckten Zoolithen unbekannter vierfüsiger Thiere, und denen sie enthaltenden, so wie verschiedenen andern denkwürdigen Grüften der Obergebürgischen Lande des Marggrafthums Bayreut. Nuremberg, Germany: Georg Wolfgang Knorrs Seel, Erben; 1774.
Granville ABXIII. An essay on Egyptian mummies; with observations on the art of embalming among the ancient Egyptians. Phil Trans R Soc. 1825;115:269–316.
doi: 10.1098/rstl.1825.0015
Zimmerman MR. An experimental study of mummification pertinent to the antiquity of cancer. Cancer. 1977;40:1358–62.
doi: 10.1002/1097-0142(197709)40:3<1358::AID-CNCR2820400354>3.0.CO;2-J
pubmed: 902245
Gaeta R, Giuffra V, Fornaciari G. Cancer in the Renaissance court of Naples. Lancet Oncol. 2017. https://doi.org/10.1016/S1470-2045(17)30464-3 .
doi: 10.1016/S1470-2045(17)30464-3
pubmed: 28759378
Fornaciari G. Histology of ancient soft tissue tumors: A review. Int J Palopathol. 2018;21:64–76.
doi: 10.1016/j.ijpp.2017.02.007
Zimmerman MR, Aufderheide AC. Seven Mummies of the Dakhleh Oasis, Egypt: Seventeen Diagnoses. Paleopathol Newsl. 2010;150:16–23.
Fornaciari G. Adenocarcinoma in the mummy of Ferrante I of Aragon, King of Naples (1431–1494). Paleopathol Newsl. 1993;82:5–8.
La FG. mummie aragonesi in San Domenico Maggiore di Napoli. Med Secoli. 2006;18:843–64.
Fornaciari G, Bruno J, Corcione N, Tornaboni D, Castagna M. Un cas de tumeur maligne primitive de la région naso-orbitaire dans une momie de la Basilique de S. Domenico Maggiore à Naples (XVI siècle). In: Proceedings of the VII European Meeting of the Paleopathology Association (Lyon, September 1988), Chieti, Italy: Journal of Paleopathology Monographic Publications, Associazione Antropologica Abruzzese; 1989, p. 65–9.
Gerszten E, Allison M. Human soft tissue tumors in Paleopathology. In: Ortner DJ, Aufderheide AC, editors. Human Paleopathology: Current syntheses and future options. Washington, DC: Smithsonian Institute; 1991. p. 260–77.