Pharmacological Effects of a New Soluble Guanylate Cyclase Stimulator in Experimental Ischemic Stroke.
endothelial dysfunction
experimental model of ischemic stroke
indolinone derivative
platelet aggregation
soluble guanylate cyclase stimulator
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
03
05
2023
medline:
1
12
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
ppublish
Résumé
We studied the action of a new indolinone derivative GRS, acetylsalicylic acid (ASA), and their combination on platelet aggregation, vasodilatory endothelial function, neurological status, and cerebral infarction area in experimental focal cerebral ischemia/reperfusion in rats. GRS compound (10 mg/kg), ASA (10 mg/kg), and their combination in the same doses were administered orally once a day as a suspension in 1% starch solution over 5 days after pathology modeling. Sham-operated and control animals were administered 1% starch solution. On day 5 after pathology modeling, platelet aggregation and brain damage area were studied in a half of rats in each group, and the vasodilatory function of the endothelium was studied in the other half. Neurological deficit was assessed 4 h and 1, 3, and 5 days after pathology modeling. GRS compound and ASA equally effectively prevent platelet aggregation and the development of neurological deficit in rats. GRS compound restores the vasodilatory effects of the endothelium, but only ASA contributes to reduction of the cerebral infarction area. In case of combined administration, GRS and ASA do not exhibit synergy in their antiaggregant effect.
Identifiants
pubmed: 37978152
doi: 10.1007/s10517-023-05938-4
pii: 10.1007/s10517-023-05938-4
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Soluble Guanylyl Cyclase
EC 4.6.1.2
Aspirin
R16CO5Y76E
Vasodilator Agents
0
Starch
9005-25-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
749-752Informations de copyright
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
Références
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