The assessment of atlantoaxial joint involvement in patients with rheumatoid arthritis, results from an observational "real-life" study.

Humans Male Female Middle Aged Aged Atlanto-Axial Joint / diagnostic imaging Cross-Sectional Studies Prospective Studies Retrospective Studies Arthritis, Rheumatoid / diagnostic imaging

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
17 11 2023
Historique:
received: 23 04 2023
accepted: 27 10 2023
medline: 20 11 2023
pubmed: 18 11 2023
entrez: 18 11 2023
Statut: epublish

Résumé

Atlantoaxial joint is a possible affected site during rheumatoid arthritis (RA) and, in this work, we evaluated its occurrence and associated characteristics in a "real-life" cohort. By a medical records review study of RA patients longitudinally followed-up, the occurrence of severe atlantoaxial joint involvement was estimated (incidence proportion and incidence rate per 1000 person-years at risk). Regression analyses were also exploited to evaluate possible associated factors. Based on these findings, a prospective recruitment was performed to build a descriptive cross-sectional study in evaluating a subclinical atlantoaxial joint involvement in patients with the same clinical characteristics. Retrospectively, 717 patients (female 56.6%, age 64.7 ± 12.3 years) were studied. The incidence proportion of severe atlantoaxial joint involvement was 2.1% [1.5-2.5], occurring in 15 out of 717 patients, and identified by both MRI and CT scan. Considering over 3091 person-years, an incidence rate of 5.2 × 1000 [2.9-8.3] person-years was estimated. Regression analyses suggested that male gender, a longer disease duration, ACPA positivity and extra-articular manifestations resulted to be significantly associated with a severe atlantoaxial joint involvement. Given these findings, 30 asymptomatic patients were selected according to these clinical characteristics and underwent MRI of cervical spine. To date, almost 50% of these asymptomatic patients showed a subclinical atlantoaxial joint involvement. The occurrence of the severe atlantoaxial joint involvement in RA patients was estimated in a "real-life" setting. Male gender, ACPA positivity, long disease duration, and extra-articular manifestations could be associated with the severe atlantoaxial joint involvement in RA. MRI could provide a useful clinical tool to early evaluate the atlantoaxial joint involvement in RA, also in asymptomatic patients.

Identifiants

DOI: 10.1038/s41598-023-46069-0 PMID: 37978246 PMC: PMC10656509
pubmed: 37978246
doi: 10.1038/s41598-023-46069-0
pii: 10.1038/s41598-023-46069-0
pmc: PMC10656509
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

20146

Informations de copyright

© 2023. The Author(s).

Références

Spine (Phila Pa 1976). 2012 Sep 15;37(20):1742-6
pubmed: 22472805
Bull NYU Hosp Jt Dis. 2011;69(2):136-48
pubmed: 22035393
Neurosurg Focus. 2015 Apr;38(4):E4
pubmed: 25828498
Curr Opin Rheumatol. 2013 May;25(3):360-6
pubmed: 23425964
Arthritis Res Ther. 2015 May 31;17:148
pubmed: 26026719
Mod Rheumatol. 2017 Jul;27(4):593-597
pubmed: 27830965
Autoimmun Rev. 2021 Feb;20(2):102735
pubmed: 33346115
Ann Rheum Dis. 2010 Sep;69(9):1580-8
pubmed: 20699241
Curr Rheumatol Rep. 2020 May 13;22(6):19
pubmed: 32405896
J Clin Epidemiol. 1996 Dec;49(12):1373-9
pubmed: 8970487
Skeletal Radiol. 2019 Apr;48(4):553-561
pubmed: 30206675
Ann N Y Acad Sci. 2006 Jun;1069:212-22
pubmed: 16855148
Radiol Med. 2019 Nov;124(11):1128-1141
pubmed: 30880357
Clin Rheumatol. 2021 Feb;40(2):547-555
pubmed: 32613395
Neurosurg Rev. 2021 Aug;44(4):1957-1965
pubmed: 33037539
Rheumatology (Oxford). 2006 May;45(5):558-65
pubmed: 16263778
Clin Rheumatol. 2017 Feb;36(2):251-260
pubmed: 27783237
J Clin Med. 2021 Oct 05;10(19):
pubmed: 34640605
Autoimmun Rev. 2019 Jan;18(1):93-106
pubmed: 30408582
Mod Rheumatol. 2010 Jun;20(3):273-9
pubmed: 20169388
Rheumatol Int. 2015 Oct;35(10):1693-9
pubmed: 25903353
Radiol Clin North Am. 2017 Sep;55(5):997-1007
pubmed: 28774459
Autoimmun Rev. 2017 Sep;16(9):911-924
pubmed: 28705780
Rheumatology (Oxford). 2021 Jan 5;60(1):471
pubmed: 32632437
Curr Rheumatol Rep. 2015 Feb;17(2):9
pubmed: 25663179
Lancet. 2016 Oct 22;388(10055):2023-2038
pubmed: 27156434
Lancet. 2010 Sep 25;376(9746):1094-108
pubmed: 20870100
Radiol Med. 2019 Nov;124(11):1121-1127
pubmed: 30771216
Clin Rheumatol. 1994 Sep;13(3):459-63
pubmed: 7835010
J Rheumatol. 2007 Aug;34(8):1670-3
pubmed: 17611987
Curr Rheumatol Rep. 2013 Oct;15(10):366
pubmed: 23955066
Rheumatology (Oxford). 2006 Dec;45(12):1558-65
pubmed: 16705046
Ann Rheum Dis. 2018 Jul;77(7):966-969
pubmed: 29588276
Clin Exp Rheumatol. 1994 Jul-Aug;12(4):369-74
pubmed: 7955599
Ann Rheum Dis. 2013 Dec;72(12):1905-13
pubmed: 23873876
Radiol Clin North Am. 2019 Sep;57(5):1051-1062
pubmed: 31351535
Autoimmun Rev. 2021 Feb;20(2):102738
pubmed: 33326854
Am J Epidemiol. 2000 Mar 1;151(5):531-9
pubmed: 10707923
J Rheumatol. 2009 Feb;36(2):273-8
pubmed: 19132793

Auteurs

Claudia Di Muzio (C)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Alessandro Conforti (A)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Federico Bruno (F)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Damiano Currado (D)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Onorina Berardicurti (O)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Luca Navarini (L)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Viktoriya Pavlych (V)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Ilenia Di Cola (I)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Alice Biaggi (A)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Stefano Di Donato (S)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Annalisa Marino (A)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Sebastiano Lorusso (S)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Francesco Ursini (F)

Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, SSD Medicina e Reumatologia, 40136, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Antonio Barile (A)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Carlo Masciocchi (C)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Paola Cipriani (P)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy.

Roberto Giacomelli (R)

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.

Piero Ruscitti (P)

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, PO Box 67100, L'Aquila, Italy. piero.ruscitti@univaq.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The assessment of atlantoaxial joint...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The assessment of atlantoaxial joint...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The assessment of atlantoaxial joint...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulation atlantoaxoïdienne › The assessment of atlantoaxial joint...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › The assessment of atlantoaxial joint...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › The assessment of atlantoaxial joint...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › The assessment of atlantoaxial joint...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › The assessment of atlantoaxial joint...