Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract.
Anoctamin 1
Anoctamin 6
Asthma
COVID-19
Cystic fibrosis
Inflammation
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
18 Nov 2023
18 Nov 2023
Historique:
received:
22
08
2023
accepted:
01
11
2023
revised:
28
10
2023
medline:
18
11
2023
pubmed:
18
11
2023
entrez:
18
11
2023
Statut:
aheadofprint
Résumé
Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral inflammatory airway infections. Here, we examined these repurposed drugs with respect to their anti-inflammatory effects in airways in vivo and in vitro. Niclosamide reduced mucus content, eosinophilic infiltration and cell death in asthmatic mouse lungs in vivo and inhibited release of interleukins in the two differentiated airway epithelial cell lines CFBE and BCi-NS1.1 in vitro. Cytokine release was also inhibited by the knockdown of the Ca
Identifiants
pubmed: 37979051
doi: 10.1007/s00424-023-02878-w
pii: 10.1007/s00424-023-02878-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s).
Références
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