The significance of mitochondrial haplogroups in preeclampsia risk.
Mitochondrial DNA
Mitochondrial haplogroups
Preeclampsia
Pregnancy
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
27
06
2023
revised:
02
10
2023
accepted:
01
11
2023
medline:
5
12
2023
pubmed:
19
11
2023
entrez:
18
11
2023
Statut:
ppublish
Résumé
To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model. This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup. No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered. Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.
Identifiants
pubmed: 37979242
pii: S2210-7789(23)00369-0
doi: 10.1016/j.preghy.2023.11.001
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
146-151Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.