RecN spatially and temporally controls RecA-mediated repair of DNA double-strand breaks.

DNA double-strand breaks DNA homologous recombination DNA repair Escherichia coli nucleoids

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
17 Nov 2023
Historique:
received: 22 09 2023
revised: 03 11 2023
accepted: 06 11 2023
pubmed: 19 11 2023
medline: 19 11 2023
entrez: 18 11 2023
Statut: aheadofprint

Résumé

RecN, a bacterial structural maintenance of chromosomes-like protein, plays an important role in maintaining genomic integrity by facilitating the repair of DNA double-strand breaks (DSBs). However, how RecN-dependent chromosome dynamics are integrated with DSB repair remains unclear. Here, we investigated the dynamics of RecN in response to DNA damage by inducing RecN from the P

Identifiants

pubmed: 37979912
pii: S0021-9258(23)02494-8
doi: 10.1016/j.jbc.2023.105466
pmc: PMC10714372
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105466

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Shunsuke Noda (S)

Department of Molecular Biology, Graduate School of Science, Gakushuin University, Tokyo, Japan.

Genki Akanuma (G)

Department of Molecular Biology, Graduate School of Science, Gakushuin University, Tokyo, Japan.

Kenji Keyamura (K)

Department of Molecular Biology, Graduate School of Science, Gakushuin University, Tokyo, Japan.

Takashi Hishida (T)

Department of Molecular Biology, Graduate School of Science, Gakushuin University, Tokyo, Japan. Electronic address: takashi.hishida@gakushuin.ac.jp.

Classifications MeSH