Survival following complete resection of neuroblastoma in novel orthotopic rat xenograft model.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 Nov 2023
18 Nov 2023
Historique:
received:
02
10
2023
accepted:
14
11
2023
medline:
27
11
2023
pubmed:
19
11
2023
entrez:
19
11
2023
Statut:
epublish
Résumé
Neuroblastoma accounts for 15% of pediatric cancer deaths, despite multimodal therapy including surgical resection. Current neuroblastoma rodent models are insufficient for studying the impact of surgery and combination treatments, largely due to the small size of mouse models. Human neuroblastoma SK-N-BE(2) cells were injected into the left adrenal gland of 5-6-week-old RNU homozygous nude rats. Rats were either monitored by MRI until humane endpoint was reached or after 5 weeks underwent operative tumor resection, followed by monitoring for recurrence and survival. Following neuroblastoma cell implantation, the majority of tumors grew to greater than 5000 mm
Identifiants
pubmed: 37980388
doi: 10.1038/s41598-023-47537-3
pii: 10.1038/s41598-023-47537-3
pmc: PMC10657433
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20214Subventions
Organisme : NCI NIH HHS
ID : R01 CA277664
Pays : United States
Organisme : NIH HHS
ID : T32CA113263
Pays : United States
Organisme : NIH HHS
ID : R01 CA277664
Pays : United States
Informations de copyright
© 2023. The Author(s).
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