DNA repair deficiency and the immune microenvironment: A pathways perspective.
DNA repair
Genome instability
Immune system
Immunotherapy
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
10
07
2023
revised:
18
09
2023
accepted:
09
11
2023
medline:
20
11
2023
pubmed:
20
11
2023
entrez:
19
11
2023
Statut:
aheadofprint
Résumé
Timely and accurate repair of DNA damage is required for genomic stability, but DNA repair pathways are often lost or altered in tumors. In addition to directly impacting tumor cell response to DNA damage, DNA repair deficiency can also alter the immune microenvironment via changes in innate and adaptive immune signaling. In some settings, these changes can lead to increased sensitivity to immune checkpoint inhibitors (ICIs). In this review, we discuss the impact of specific DNA repair pathway dysfunction on immune contexture and ICI response in solid tumors.
Identifiants
pubmed: 37980867
pii: S1568-7864(23)00148-9
doi: 10.1016/j.dnarep.2023.103594
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103594Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors disclose no potential conflicts of interest.