Hippocampal Connectivity with the Default Mode Network is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals.
Journal
Clinical psychological science : a journal of the Association for Psychological Science
ISSN: 2167-7026
Titre abrégé: Clin Psychol Sci
Pays: United States
ID NLM: 101601751
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
20
11
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
ppublish
Résumé
Reduced hippocampal volume (HV) is an established brain morphological feature of psychiatric conditions. HV is associated with brain connectivity in humans and non-human animals and altered connectivity is associated with risk for psychiatric illness. Associations between HV and connectivity remain poorly characterized in humans, and especially in phases of psychiatric illness that precede disease onset. This study examined associations between HV and hippocampal functional connectivity (FC) during rest in 141 healthy controls and 248 individuals at-risk for psychosis. Significant inverse associations between HV and hippocampal FC with the inferior parietal lobe (IPL) and thalamus were observed. Select associations between hippocampal FC and HV were moderated by diagnostic group. Significant moderation results shifted from implicating the IPL to the temporal pole after excluding participants on antipsychotic medication. Considered together, this work implicates hippocampal FC with the temporoparietal junction, within a specialized subsystem of the default mode network, as sensitive to HV.
Identifiants
pubmed: 37981950
doi: 10.1177/21677026221138819
pmc: PMC10656030
mid: NIHMS1846073
doi:
Types de publication
Journal Article
Langues
eng
Pagination
801-818Subventions
Organisme : NIMH NIH HHS
ID : U01 MH081902
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076989
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081988
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH066286
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH076989
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081928
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH082022
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081984
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081857
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH082004
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081944
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest The authors declare that there were no conflicts of interest with respect to the authorship or the publication of this article.
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