Particle ID: A Multiplexed Hydrogel Bead Platform for Biomedical Applications.
3D bead-based immunoassay
barcoding of beads
biofunctionalization of beads
borelliosis
hydrogel beads
multiplexing
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
pmc-release:
20
11
2024
medline:
11
12
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
ppublish
Résumé
We present a new platform based on hydrogel beads for multiplex analysis that can be fabricated, barcoded, and functionalized in a single step using a simple microfluidic assembly and a photo-cross-linking process. The beads are generated in a two-phase flow fluidic system and photo-cross-linking of the polymer in the aqueous phase by C,H insertion cross-linking (CHic). The size and shape of the hydrogel particles can be controlled over a wide range by fluidic parameters. During the fabrication of the beads, they are barcoded by using physical and optical barcoding strategies. Magnetic beads and fluorescent particles, which allow identification of the production batch number, are added simultaneously as desired, resulting in complex, multifunctional beads in a one-step reaction. As an example of biofunctionalization,
Identifiants
pubmed: 37982803
doi: 10.1021/acsami.3c12122
pmc: PMC10712431
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
55346-55357Références
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