Adjuvant Auger Electron-Emitting Radioimmunotherapy with [

Humans Animals Mice Panitumumab Triple Negative Breast Neoplasms / drug therapy Radioimmunotherapy ErbB Receptors / metabolism Positron Emission Tomography Computed Tomography Electrons Immunoglobulin G
Auger electrons epidermal growth factor receptors (EGFR) indium-111 panitumumab triple-negative breast cancer (TNBC)

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
04 Dec 2023
Historique:
medline: 5 12 2023
pubmed: 20 11 2023
entrez: 20 11 2023
Statut: ppublish

Résumé

Triple-negative breast cancer (TNBC) has a high risk for recurrence and metastasis. We studied the effectiveness of Auger electron (AE) radioimmunotherapy (RIT) with antiepidermal growth factor receptor (EGFR) panitumumab conjugated with DOTA complexed to

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c00780 PMID: 37983089
pubmed: 37983089
doi: 10.1021/acs.molpharmaceut.3c00780
doi:

Substances chimiques

Panitumumab 6A901E312A
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 1HTE449DGZ
ErbB Receptors EC 2.7.10.1
Indium-111 E9NGC49E0T
Immunoglobulin G 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6407-6419

Auteurs

Valerie J Facca (VJ)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
ORCID: 0000-0001-5909-883X

Zhongli Cai (Z)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
ORCID: 0000-0002-8937-4943

Anthony Ku (A)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.

Constantine J Georgiou (CJ)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
ORCID: 0000-0002-0602-9416

Raymond M Reilly (RM)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
Department of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Joint Department of Medical Imaging and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada.
ORCID: 0000-0003-1038-7993

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Eucaryotes › Animaux › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Panitumumab › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radioimmunothérapie › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électrons › Adjuvant Auger Electron-Emitting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Adjuvant Auger Electron-Emitting...