The cyclophilin A-binding loop of the capsid regulates the human TRIM5α sensitivity of nonpandemic HIV-1.
HIV-1
TRIM5
capsid
cyclophilin
restriction factor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
pmc-release:
20
05
2024
medline:
22
11
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
ppublish
Résumé
The rather few cases of humans infected by HIV-1 N, O, or P raise the question of their incomplete adaptation to humans. We hypothesized that early postentry restrictions may be relevant for the impaired spread of these HIVs. One of the best-characterized species-specific restriction factors is TRIM5α. HIV-1 M can escape human (hu) TRIM5α restriction by binding cyclophilin A (CYPA, also known as PPIA, peptidylprolyl isomerase A) to the so-called CYPA-binding loop of its capsid protein. How non-M HIV-1s interact with huTRIM5α is ill-defined. By testing full-length reporter viruses (Δ
Identifiants
pubmed: 37983491
doi: 10.1073/pnas.2306374120
pmc: PMC10691330
doi:
Substances chimiques
Cyclophilin A
EC 5.2.1.-
Capsid Proteins
0
Tripartite Motif Proteins
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2306374120Subventions
Organisme : Deutscher Akademischer Austauschdienst (DAAD)
ID : 91611196
Organisme : CSC | Chinese Government Scholarship
ID : 983123
Organisme : Heinz Ansmann Foundation
ID : 00000
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 270650915
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.
Références
Front Microbiol. 2021 Apr 01;12:652486
pubmed: 33868211
Nat Struct Biol. 2003 Jun;10(6):475-81
pubmed: 12730686
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5247-52
pubmed: 11929983
Nat Struct Biol. 2002 Jul;9(7):537-43
pubmed: 12032547
PLoS Pathog. 2013 Mar;9(3):e1003214
pubmed: 23505372
J Virol. 2011 Jan;85(1):542-9
pubmed: 20962083
Cold Spring Harb Perspect Med. 2012 May;2(5):a006940
pubmed: 22553496
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1298-303
pubmed: 12547912
Retrovirology. 2005 Jun 20;2:40
pubmed: 15967037
J Chem Phys. 2004 Jun 22;120(24):11432-41
pubmed: 15268177
J Phys Chem B. 2009 Dec 31;113(52):16590-5
pubmed: 19938868
Cell. 1996 Dec 27;87(7):1285-94
pubmed: 8980234
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18372-7
pubmed: 23091002
J Chem Theory Comput. 2015 Apr 14;11(4):1645-57
pubmed: 26574374
Cell Rep. 2020 Mar 17;30(11):3766-3777.e6
pubmed: 32187548
J Phys Chem Lett. 2014 Nov 6;5(21):3863-3871
pubmed: 25400877
Nature. 1994 Nov 24;372(6504):359-62
pubmed: 7969494
Med Microbiol Immunol. 2023 Apr;212(2):133-140
pubmed: 35333966
Nature. 2004 Jul 29;430(6999):569-73
pubmed: 15243629
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14617-22
pubmed: 26553990
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3569-74
pubmed: 18287033
J Chem Theory Comput. 2020 Jan 14;16(1):528-552
pubmed: 31714766
J Virol. 1998 Nov;72(11):8463-71
pubmed: 9765382
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3563-8
pubmed: 18287034
Nat Microbiol. 2019 Jun;4(6):933-940
pubmed: 30886358
J Biol Chem. 2012 Nov 30;287(49):40875-83
pubmed: 23043100
Nat Microbiol. 2022 Nov;7(11):1762-1776
pubmed: 36289397
J Chem Inf Model. 2019 Jun 24;59(6):2522-2528
pubmed: 31120747
J Virol. 2000 Aug;74(16):7422-30
pubmed: 10906195
Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2306374120
pubmed: 37983491
AIDS Rev. 2015 Jul-Sep;17(3):147-58
pubmed: 26450803
Nat Microbiol. 2019 Dec;4(12):2044-2051
pubmed: 31636416
J Virol. 2005 Dec;79(24):15175-88
pubmed: 16306589
Science. 1999 Jan 1;283(5398):80-3
pubmed: 9872746
Microorganisms. 2020 Dec 11;8(12):
pubmed: 33322320
J Virol. 2007 Jul;81(14):7463-75
pubmed: 17494082
Front Microbiol. 2012 Jan 24;3:13
pubmed: 22291694
Nat Rev Microbiol. 2019 Sep;17(9):546-556
pubmed: 31312031
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Cell Host Microbe. 2009 Nov 19;6(5):409-21
pubmed: 19917496
Proteins. 2009 Dec;77(4):778-95
pubmed: 19603484
Nat Med. 2003 Sep;9(9):1138-43
pubmed: 12897779
J Virol. 2008 Jul;82(13):6772-7
pubmed: 18417575
J Virol. 2012 Apr;86(8):4708-14
pubmed: 22301145
Cell Host Microbe. 2019 Jan 9;25(1):27-38
pubmed: 30629915
J Virol. 2020 Nov 9;94(23):
pubmed: 32907979
J Chem Theory Comput. 2020 Mar 10;16(3):1953-1967
pubmed: 31967823
Nat Commun. 2020 Mar 11;11(1):1307
pubmed: 32161265
J Comput Chem. 2012 Feb 5;33(4):453-65
pubmed: 22109354
J Virol. 2018 Nov 27;92(24):
pubmed: 30258007
J Mol Biol. 1997 Jun 27;269(5):780-95
pubmed: 9223641
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006841
pubmed: 22229120
Nat Struct Mol Biol. 2009 Oct;16(10):1036-42
pubmed: 19767750
PLoS Pathog. 2011 Dec;7(12):e1002439
pubmed: 22174692
Nature. 2011 Apr 21;472(7343):361-5
pubmed: 21512573
Retrovirology. 2019 Apr 4;16(1):10
pubmed: 30947724
PLoS One. 2012;7(12):e50859
pubmed: 23227216
EMBO J. 2001 May 1;20(9):2140-51
pubmed: 11331580
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3557-62
pubmed: 18287035
Science. 2015 Jul 3;349(6243):99-103
pubmed: 26044298
J Chem Theory Comput. 2011 Feb 8;7(2):525-37
pubmed: 26596171
Nature. 1994 Nov 24;372(6504):363-5
pubmed: 7969495
PLoS Pathog. 2017 Jul 3;13(7):e1006466
pubmed: 28672035
Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6
pubmed: 22407016