Natural probiotics improve heritable sterility.
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
received:
13
10
2023
accepted:
18
10
2023
medline:
11
12
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
ppublish
Résumé
Disrupting the small RNA pathway and chromatin-modifying enzymes in C. elegans often leads to a mortal germline (Mrt) phenotype, characterized by progressive sterility observed over multiple generations at elevated temperature. This phenotype arises from the inheritance of aberrant epigenetic memory across generations. In this issue of EMBO Reports, Frézal and colleagues reported that, while in standard laboratory environment C. elegans wild isolates exhibit the Mrt phenotype, sterility does not occur when the worms are exposed to naturally associated bacteria and microsporidia. Excitingly, diet-induced epigenetic memory may persist for multiple generations. This suggests intriguing diet-gene interactions in modulating nongenetic inheritance, potentially shaping the evolutionary trajectory of the animals.
Identifiants
pubmed: 37983676
doi: 10.15252/embr.202358318
pmc: PMC10702800
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e58318Subventions
Organisme : EC | European Research Council (ERC)
ID : 335624
Organisme : Eric and Wendy Schmidt Fund for Strategic Innovation
ID : Polymath Award #0140001000
Organisme : European Molecular Biology Organization (EMBO)
ID : ALTF 6-2022
Organisme : Morris Kahn Foundation
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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