Leukocyte ratios in non-diabetic hypertensive Cameroonians do not predict cardiovascular risk : preliminary results of the HYRICCA project.
Arterial hypertension Cardiovascular risk Hypertension artérielle Leukocyte ratios Ratios leucocytaires Risque cardiovasculaire

Journal

Annales de cardiologie et d'angeiologie
ISSN: 1768-3181
Titre abrégé: Ann Cardiol Angeiol (Paris)
Pays: France
ID NLM: 0142167

Informations de publication

Date de publication:
18 Nov 2023
Historique:
received: 30 07 2023
revised: 29 08 2023
accepted: 26 09 2023
medline: 21 11 2023
pubmed: 21 11 2023
entrez: 20 11 2023
Statut: aheadofprint

Résumé

Full blood count is routinely performed in the evaluation of hypertensive patients. However, usefulness of leukocyte ratios in cardiovascular risk (CVR) assessment hasn't yet been proven in Cameroonians. Evaluate the contribution of leukocyte ratios in CVR assessment of non-diabetic hypertensive adults. We carried out a cross sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. We collected relevant clinical data with a pre-established questionnaire and blood samples from each patient for different biological analyses. The spearman correlation test was used to assess on the one hand the relationship between leukocyte ratios, highly sensitive CRP and the WHO 2019 risk score as our primary end point, and on the other hand between leukocyte indices and the other risk estimators as our secondary outcome. The significant threshold level was set as 0.05. We included 165 participants (102 females) with a mean age of 57.6 (10.4) years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had a controlled blood pressure. There was no significant correlation between leukocyte ratios and the WHO 2019 risk score. Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the granulocyte to lymphocyte ratio (rho = 0.18, p = 0.03) and the eosinophil to lymphocyte ratio (rho = 0.28, p = 0.01). There exists a weak positive association between the granulocyte to lymphocyte ratio and the Reynolds risk score. Leukocyte ratios are not useful for CVR assessment in hypertensive Cameroonians with respect to the WHO 2019 risk score. Prospective studies are needed to assess their usefulness in combination with conventional risk factors to improve prediction of cardiovascular events.

Sections du résumé

BACKGROUND BACKGROUND
Full blood count is routinely performed in the evaluation of hypertensive patients. However, usefulness of leukocyte ratios in cardiovascular risk (CVR) assessment hasn't yet been proven in Cameroonians.
OBJECTIVE OBJECTIVE
Evaluate the contribution of leukocyte ratios in CVR assessment of non-diabetic hypertensive adults.
METHODOLOGY METHODS
We carried out a cross sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. We collected relevant clinical data with a pre-established questionnaire and blood samples from each patient for different biological analyses. The spearman correlation test was used to assess on the one hand the relationship between leukocyte ratios, highly sensitive CRP and the WHO 2019 risk score as our primary end point, and on the other hand between leukocyte indices and the other risk estimators as our secondary outcome. The significant threshold level was set as 0.05.
RESULTS RESULTS
We included 165 participants (102 females) with a mean age of 57.6 (10.4) years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had a controlled blood pressure. There was no significant correlation between leukocyte ratios and the WHO 2019 risk score. Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the granulocyte to lymphocyte ratio (rho = 0.18, p = 0.03) and the eosinophil to lymphocyte ratio (rho = 0.28, p = 0.01). There exists a weak positive association between the granulocyte to lymphocyte ratio and the Reynolds risk score.
CONCLUSION CONCLUSIONS
Leukocyte ratios are not useful for CVR assessment in hypertensive Cameroonians with respect to the WHO 2019 risk score. Prospective studies are needed to assess their usefulness in combination with conventional risk factors to improve prediction of cardiovascular events.

Identifiants

DOI: 10.1016/j.ancard.2023.101679 PMID: 37984238
pubmed: 37984238
pii: S0003-3928(23)00114-2
doi: 10.1016/j.ancard.2023.101679
pii:
doi:

Types de publication

English Abstract Journal Article

Langues

fre

Sous-ensembles de citation

IM

Pagination

101679

Informations de copyright

Copyright © 2023 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no competing interests.

Auteurs

Jan René Nkeck (JR)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: jrnkeck@gmail.com.

Claudine Jessica Yondo Ndedi (CJ)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: ndedijessica@gmail.com.

Liliane Mfeukeu Kuate (L)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Cardiology department, Yaoundé Central Hospital, Yaoundé, Cameroon. Electronic address: mfeukeuliliane@gmail.com.

Annick Ndoumba Mintya (A)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Hematology Laboratory, Yaoundé University Teaching Hospital, Yaoundé, Cameroon. Electronic address: ndoumbaannick@yahoo.fr.

Marie Ida Chemgne (MI)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: idchemgne13@gmail.com.

Joachim Tchikapa (J)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: tchikapajoachim@yahoo.com.

Larissa Ange Tchuisseu Kwangoua (LA)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon; Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Electronic address: tchosange@yahoo.fr.

Charelle Boukeu Yonta (C)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: charelleboukeu@gmail.com.

Corine Zouague Zalbi (C)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: corinezalbi96@gmail.com.

Andrée Ntyam Abena (A)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: ornellaabena97@gmail.com.

Falmata Amazia (F)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon. Electronic address: falmataamazia@yahoo.fr.

Vicky Jocelyne Ama Moor (VJ)

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais) research team, Cameroon; Biochemistry Laboratory of the Yaoundé University Teaching Hospital, Yaoundé, Cameroon. Electronic address: movicky@yahoo.fr.

Classifications MeSH