Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.
Alzheimer's disease
amyloid beta
dementia
exercise
genetics
longitudinal
physical activity
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
revised:
13
10
2023
received:
26
07
2023
accepted:
23
10
2023
medline:
21
11
2023
pubmed:
21
11
2023
entrez:
20
11
2023
Statut:
aheadofprint
Résumé
The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = -54.26, p = 0.59). Our study did not identify a relationship between habitual PA and brain Aβ levels. Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Alzheimer's Association
Pays : United States
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014;13:614-629.
Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 2008;131:1630-1645.
Masters CL, Beyreuther K. Neuronal origin of cerebral amyloidogenic proteins: their role in Alzheimer's disease and unconventional virus diseases of the nervous system. Ciba Found Symp. 1987;126:49-64.
Masters CL, Beyreuther K. Molecular neuropathology of Alzheimer's disease. Arzneimittelforschung. 1995;45:410-412.
Villemagne VL, Burnham S, Bourgeat P, et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. The Lancet Neurology. 2013;12:357-367.
Lim YY, Maruff P, Kaneko N, et al. Plasma amyloid-β biomarker associated with cognitive decline in preclinical Alzheimer's disease. J Alzheimers Dis. 2020;77:1057-1065.
Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
Di Liegro CM, Schiera G, Proia P, Di Liegro I. Physical activity and brain health. Genes. 2019;10:720.
Blondell SJ, Hammersley-Mather R, Veerman JL. Does physical activity prevent cognitive decline and dementia?: a systematic review and meta-analysis of longitudinal studies. BMC Public Health. 2014;14:510.
Brown BM, Peiffer J, SR Rainey-Smith. Exploring the relationship between physical activity, beta-amyloid and tau: a narrative review. Ageing Research Reviews. 2019;50:9-18.
Frederiksen KS, Gjerum L, Waldemar G, Hasselbalch SG. Physical activity as a moderator of alzheimer pathology: a systematic review of observational studies. Curr Alzheimer Res. 2019a;16:362-378.
Haan MN, Wallace R. Can dementia be prevented? Brain aging in a population-based context. Annual Review of Public Health. 2004;25:1-24.
Guure CB, Ibrahim NA, Adam MB, Said SM. Impact of physical activity on cognitive decline, dementia, and its subtypes: meta-analysis of prospective studies. BioMed Research International. 2017;2017:1-13.
Sabia S, Dugravot A, Dartigues J-F, et al. Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017:j2709.
Brown BM, Peiffer JJ, Taddei K, et al. Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging. Biomarkers and Lifestyle Study of Ageing Molecular Psychiatry. 2013b;18:875-881.
Brown BM, Rainey-Smith SR, Dore V, et al. Self-reported physical activity is associated with tau burden measured by positron emission tomography. J Alzheimers Dis. 2018;63:1299-1305.
Head D, Bugg JM, Goate AM, et al. Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol. 2012;69:636-643.
Liang KY, Mintun MA, Fagan AM, et al. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of Neurology. 2010;68:311-318.
Okonkwo OC, Schultz SA, Oh JM, et al. Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 2014;83:1753-1760.
Rabin JS, Klein H, Kirn DR, et al. Associations of Physical activity and β-Amyloid with longitudinal cognition and neurodegeneration in clinically normal older adults. JAMA Neurology. 2019;76:1203.
Treyer V, Meyer RS, Buchmann A, et al. Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging. PLOS ONE. 2021;16:e0247225.
de Souto Barreto P, Andrieu S, Payoux P, Demougeot L, Rolland Y, Vellas B. Physical activity and amyloid-β brain levels in elderly adults with intact cognition and mild cognitive impairment. Journal of the American Geriatrics Society. 2015;63:1634-1639.
Pedrero-Chamizo R, Szoeke C, Dennerstein L, Campbell S. Influence of physical activity levels and functional capacity on brain β-amyloid deposition in older women. Front Aging Neurosci. 2021;13:697528.
Craft S, Cholerton B, Baker LD. Insulin and Alzheimer's disease: untangling the web. J Alzheimers Dis. 2013;33(1):S263-S275. Suppl.
Gasparini L, Gouras GK, Wang R, et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci. 2001;21:2561-2570.
Alkadhi KA, Dao AT. Exercise decreases BACE and APP levels in the hippocampus of a rat model of Alzheimer's disease. Molecular and Cellular Neuroscience. 2018;86:25-29.
Koo JH, Kang EB, Oh YS, Yang DS, Cho JY. Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease. Experimental Neurology. 2017;288:142-152.
Zhang J, Guo Y, Wang Y, Song L, Zhang R, Du Y. Long-term treadmill exercise attenuates Aβ burdens and astrocyte activation in APP/PS1 mouse model of Alzheimer's disease. Neurosci Lett. 2018;666:70-77.
Nigam SM, Xu S, Kritikou JS, Marosi K, Brodin L, Mattson MP. Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP. Journal of Neurochemistry. 2017;142:286-296.
de Frutos-Lucas J, Frost N, Erickson KI, et al. Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review. Ageing Res Rev. 2020;64:101173.
Doré V, Bullich S, Rowe CC, et al. Comparison of 18 F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL ® approaches: validation against histopathology. Alzheimer's & Dementia. 2019;15:807-816.
Bourgeat P, Doré V, Fripp J, et al. Implementing the centiloid transformation for 11C-PiB and β-amyloid 18F-PET tracers using CapAIBL. NeuroImage. 2018;183:387-393.
Klunk WE, Koeppe RA, Price JC, et al. The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimer's & Dementia. 2015;11:1-15.
Fowler C, Rainey-Smith SR, Bird S, et al. Fifteen Years of the australian imaging, biomarkers and lifestyle (AIBL) Study: progress and Observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer's disease. J Alzheimers Dis Rep. 2021;5:443-468.
Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-Country reliability and validity. Medicine & Science in Sports & Exercise. 2003;35:1381-1395.
Cleland C, Ferguson S, Ellis G, Hunter RF. Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom. BMC Medical Research Methodology. 2018;18.
R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2021
Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Annals of Neurology. 2008;64:492-498.
Rowe CC, Bourgeat P, Ellis KA, et al. Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology. 2013;74:905-913.
Frederiksen KS, Madsen K, Andersen BB, et al. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2019b;5:208-215.
Vidoni ED, Morris JK, Watts A, et al. Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer's: a 1-year randomized controlled trial. PLOS ONE. 2021;16:e0244893.
Walters MJ, Sterling J, Quinn C, et al. Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area. BMJ Open. 2018;8:e023664.
Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43:1334-1359.
World Health Organisation. Global Recommendations on Physical Activity for Health. 2010
Australian Bureau of Statistics. Physical activity. In: ABS, editor. 2017-18
Australian Bureau of Statistics. Physical activity. In: ABS, editor. 2020-21
Bachmann D, Roman ZJ, Buchmann A, et al. Lifestyle affects amyloid burden and cognition differently in men and women. Annals of Neurology. 2022;92:451-463.
Pearce AM, Marr C, Dewar M, Gow AJ. Apolipoprotein E genotype moderation of the association between physical activity and brain health. A systematic review and meta-analysis. Front Aging Neurosci. 2021;13:815439.
Brown BM, Peiffer JJ, Martins RN. Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease? Molecular Psychiatry. 2013a;18:864-874.
Cotman CW, Engesser-Cesar C. Exercise enhances and protects brain function. Exercise and Sport Sciences Reviews. 2002;30:75-79.
Silsbury Z, Goldsmith R, Rushton A. Systematic review of the measurement properties of self-report physical activity questionnaires in healthy adult populations: figure 1. BMJ Open. 2015;5:e008430.
Law LL, Rol RN, Schultz SA, et al. Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease. Alzheimer's & Dementia: diagnosis. Assessment & Disease Monitoring. 2018;10:188-195.