A review of chitosan in gene therapy: Developments and challenges.

Chitosan Transfection Genetic Therapy Genetic Vectors Gene Transfer Techniques Nucleic Acids
Chitosan Gene delivery Non-viral vector Polysaccharide

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 18 08 2023
revised: 14 10 2023
accepted: 03 11 2023
medline: 22 11 2023
pubmed: 21 11 2023
entrez: 20 11 2023
Statut: ppublish

Résumé

Gene therapy, as a revolutionary treatment, has been gaining more and more attention. The key to gene therapy is the selection of suitable vectors for protection of exogenous nucleic acid molecules and enabling their specific release in target cells. While viral vectors have been widely used in researches, non-viral vectors are receiving more attention due to its advantages. Chitosan (CS) has been widely used as non-viral organic gene carrier because of its good biocompatibility and its ability to load large amounts of nucleic acids. This paper summarizes and evaluates the potential of chitosan and its derivatives as gene delivery vector materials, along with factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and the current main research development directions. Additionally, it provides an outlook on its future prospects.

Identifiants

DOI: 10.1016/j.carbpol.2023.121562 PMID: 37985064
pubmed: 37985064
pii: S0144-8617(23)01027-5
doi: 10.1016/j.carbpol.2023.121562
pii:
doi:

Substances chimiques

Chitosan 9012-76-4
Nucleic Acids 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

121562

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Liang Dong (L)

College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.

Yanan Li (Y)

College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.

Hailin Cong (H)

College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China; School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China. Electronic address: conghailin@sdut.edu.cn.

Bing Yu (B)

College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China. Electronic address: yubing198@qdu.edu.cn.

Youqing Shen (Y)

College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › A review of chitosan in gene therapy:...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › A review of chitosan in gene therapy:...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › A review of chitosan in gene therapy:...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Vecteurs génétiques › A review of chitosan in gene therapy:...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de transfert de gènes › A review of chitosan in gene therapy:...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › A review of chitosan in gene therapy:...