Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal adenocarcinoma.
Cancer
Gene-environment interaction
Polygenic risk score
SNPs
UK Biobank
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
18 Nov 2023
18 Nov 2023
Historique:
received:
03
07
2023
revised:
05
10
2023
accepted:
18
10
2023
medline:
21
11
2023
pubmed:
21
11
2023
entrez:
20
11
2023
Statut:
aheadofprint
Résumé
The current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk factors is limited and no study has comprehensively tested the exposome in combination with the genetic variability in relation to the disease susceptibility. The aim of this study was to analyze the exposome and its interaction with known genetic susceptibility loci, in relation to PDAC risk. A case-control study nested in UK Biobank cohort was conducted on 816 PDAC cases and 302,645 controls. A total of 347 exposure variables, and a polygenic risk score (PRS) were analyzed through logistic regression. Gene-environment interaction analyses were conducted. A total of 52 associations under the Bonferroni corrected threshold of p < 1.46 × 10 In conclusion, our results suggest that a stressful lifestyle and sedentary behaviors may play a major role in PDAC susceptibility independently from the genetic background.
Sections du résumé
BACKGROUND
BACKGROUND
The current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk factors is limited and no study has comprehensively tested the exposome in combination with the genetic variability in relation to the disease susceptibility.
AIM
OBJECTIVE
The aim of this study was to analyze the exposome and its interaction with known genetic susceptibility loci, in relation to PDAC risk.
METHODS
METHODS
A case-control study nested in UK Biobank cohort was conducted on 816 PDAC cases and 302,645 controls. A total of 347 exposure variables, and a polygenic risk score (PRS) were analyzed through logistic regression. Gene-environment interaction analyses were conducted.
RESULTS
RESULTS
A total of 52 associations under the Bonferroni corrected threshold of p < 1.46 × 10
CONCLUSION
CONCLUSIONS
In conclusion, our results suggest that a stressful lifestyle and sedentary behaviors may play a major role in PDAC susceptibility independently from the genetic background.
Identifiants
pubmed: 37985251
pii: S1590-8658(23)01004-6
doi: 10.1016/j.dld.2023.10.015
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Conflict of interest All the authors have no conflicts of interest to declare.