Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues.
RNA sequencing
ovary
rete ovarii
single-cell transcriptomics
single-nucleus transcriptomics
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
06 Nov 2023
06 Nov 2023
Historique:
pubmed:
21
11
2023
medline:
21
11
2023
entrez:
21
11
2023
Statut:
epublish
Résumé
The rete ovarii (RO) is an epithelial structure that arises during fetal development in close proximity to the ovary and persists throughout adulthood in mice. However, the functional significance of the RO remains elusive, and it has been absent from recent discussions of female reproductive anatomy. The RO comprises three distinct regions: the intraovarian rete (IOR) within the ovary, the extraovarian rete (EOR) in the periovarian tissue, and the connecting rete (CR) linking the EOR and IOR. We hypothesize that the RO plays a pivotal role in maintaining ovarian homeostasis and responding to physiological changes. To uncover the nature and function of RO cells, we conducted transcriptome analysis, encompassing bulk, single-cell, and nucleus-level sequencing of both fetal and adult RO tissues using the
Identifiants
pubmed: 37986846
doi: 10.1101/2023.11.06.565717
pmc: PMC10659311
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NICHD NIH HHS
ID : K99 HD103778
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD103778
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD039963
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD090050
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
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