RNA structure modulates Cas13 activity and enables mismatch detection.
CRISPR
Cas13
RNA detection
RNA structure
strand displacement
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
pubmed:
21
11
2023
medline:
21
11
2023
entrez:
21
11
2023
Statut:
epublish
Résumé
The RNA-targeting CRISPR nuclease Cas13 has emerged as a powerful tool for applications ranging from nucleic acid detection to transcriptome engineering and RNA imaging
Identifiants
pubmed: 37987004
doi: 10.1101/2023.10.05.560533
pmc: PMC10659300
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : DP2 AI175474
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI168808
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007388
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM148739
Pays : United States
Déclaration de conflit d'intérêts
Competing interests C.M. is a co-founder and consultant to Carver Biosciences and holds equity in the company. All authors (O.K., B.B.L., O.R.S.D., A.J.W.t.V., C.M) are co-inventors on a patent application relating to this study.
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