Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder.
REM suppression
adolescent
depression
polysomnography
sleep architecture
vortioxetine
Journal
Clocks & sleep
ISSN: 2624-5175
Titre abrégé: Clocks Sleep
Pays: Switzerland
ID NLM: 101736579
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
received:
25
08
2023
revised:
17
10
2023
accepted:
22
10
2023
medline:
21
11
2023
pubmed:
21
11
2023
entrez:
21
11
2023
Statut:
epublish
Résumé
The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (
Identifiants
pubmed: 37987393
pii: clockssleep5040042
doi: 10.3390/clockssleep5040042
pmc: PMC10660849
doi:
Types de publication
Journal Article
Langues
eng
Pagination
627-638Subventions
Organisme : Comenius University Grant
ID : UK/12/2021
Organisme : The Slovak Scientific Grant Agency VEGA
ID : 1/0190/20
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