Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.

Animals Humans Macrophage Migration-Inhibitory Factors / genetics Plant Proteins Receptors, CXCR4 / genetics Saccharomyces cerevisiae / metabolism Neutrophils / metabolism Mammals / metabolism Intramolecular Oxidoreductases / genetics

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
21 Nov 2023
Historique:
medline: 23 11 2023
pubmed: 21 11 2023
entrez: 21 11 2023
Statut: ppublish

Résumé

Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory cytokines. Plants have orthologous MIF and D-dopachrome tautomerase-like (MDL) proteins that mimic some of the effects of MIF on immune cells in vitro. We explored the structural and functional similarities between the three

Identifiants

DOI: 10.1126/scisignal.adg2621 PMID: 37988455
pubmed: 37988455
doi: 10.1126/scisignal.adg2621
doi:

Substances chimiques

Macrophage Migration-Inhibitory Factors 0
Plant Proteins 0
Receptors, CXCR4 0
MIF protein, human EC 5.3.2.1
Intramolecular Oxidoreductases EC 5.3.-
CXCR4 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg2621

Auteurs

Lukas Spiller (L)

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
ORCID: 0000-0002-7214-1983

Ramu Manjula (R)

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06510, USA.
ORCID: 0000-0002-2237-2599

Franz Leissing (F)

Unit of Plant Molecular Cell Biology, Institute for Biology I, RWTH Aachen University, 52056 Aachen, Germany.
ORCID: 0000-0002-9746-7162

Jerome Basquin (J)

Department of Structural Cell Biology and Crystallization Facility, Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany.

Priscila Bourilhon (P)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
ORCID: 0000-0002-0693-4467

Dzmitry Sinitski (D)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.

Markus Brandhofer (M)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
ORCID: 0000-0002-1629-8353

Sophie Levecque (S)

Unit of Plant Molecular Cell Biology, Institute for Biology I, RWTH Aachen University, 52056 Aachen, Germany.
ORCID: 0000-0002-2056-1193

Simona Gerra (S)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
ORCID: 0009-0005-6061-5124

Björn Sabelleck (B)

Unit of Plant Molecular Cell Biology, Institute for Biology I, RWTH Aachen University, 52056 Aachen, Germany.
ORCID: 0000-0003-4552-7589

Lin Zhang (L)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
Department of Anesthesiology, LMU University Hospital, 81377 Munich, Germany.
ORCID: 0000-0001-8463-2141

Regina Feederle (R)

Monoclonal Antibody Core Facility, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
ORCID: 0000-0002-3981-367X

Andrew Flatley (A)

Monoclonal Antibody Core Facility, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
ORCID: 0000-0001-7822-132X

Adrian Hoffmann (A)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
Department of Anesthesiology, LMU University Hospital, 81377 Munich, Germany.

Ralph Panstruga (R)

Unit of Plant Molecular Cell Biology, Institute for Biology I, RWTH Aachen University, 52056 Aachen, Germany.
ORCID: 0000-0002-3756-8957

Jürgen Bernhagen (J)

Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-Universität (LMU) München, LMU University Hospital, 81377 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
ORCID: 0000-0003-2996-2652

Elias Lolis (E)

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06510, USA.
ORCID: 0000-0002-7902-7868

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs inhibiteurs de la migration des macrophages › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Plant MDL proteins synergize with the cytokine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Plant MDL proteins synergize with the cytokine...