Cardiac human bitter taste receptors contain naturally occurring variants that alter function.
Cardiovascular
Cell signaling
Genetic polymorphism
Physiology
Taste receptor subtype 2
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
19 Nov 2023
19 Nov 2023
Historique:
received:
13
07
2023
revised:
26
10
2023
accepted:
16
11
2023
pubmed:
22
11
2023
medline:
22
11
2023
entrez:
21
11
2023
Statut:
aheadofprint
Résumé
Bitter taste receptors (T2R) are a subfamily of G protein-coupled receptors that enable humans to detect aversive and toxic substances. The ability to discern bitter compounds varies between individuals and is attributed mainly to naturally occurring T2R polymorphisms. T2Rs are also expressed in numerous non-gustatory tissues, including the heart, indicating potential contributions to cardiovascular physiology. In this study. T2Rs that have previously been identified in human cardiac tissues (T2Rs - 10, 14, 30, 31, 46 and 50) and their naturally occurring polymorphisms were functionally characterised. The ligand-dependent signaling responses of some T2R variants were completely abolished (T2R30 Leu
Identifiants
pubmed: 37989413
pii: S0006-2952(23)00525-7
doi: 10.1016/j.bcp.2023.115932
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115932Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.