Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice.
1H magic angle spinning nuclear magnetic resonance
Fetal brain
Metabolomics
Mouse
Nanoplastics
Pregnancy
Journal
Metabolomics : Official journal of the Metabolomic Society
ISSN: 1573-3890
Titre abrégé: Metabolomics
Pays: United States
ID NLM: 101274889
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
23
08
2023
accepted:
31
10
2023
medline:
23
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
epublish
Résumé
Plastics used in everyday materials accumulate as waste in the environment and degrade over time. The impacts of the resulting particulate micro- and nanoplastics on human health remain largely unknown. In pregnant mice, we recently demonstrated that exposure to nanoplastics throughout gestation and during lactation resulted in changes in brain structure detected on MRI. One possible explanation for this abnormal postnatal brain development is altered fetal brain metabolism. To determine the effect of maternal exposure to nanoplastics on fetal brain metabolism. Healthy pregnant CD-1 mice were exposed to 50 nm polystyrene nanoplastics at a concentration of 10 The relative concentrations of gamma-aminobutyric acid (GABA), creatine and glucose were found to decrease by 40%, 21% and 30% respectively following maternal nanoplastic exposure when compared to the controls (p < 0.05). The change in relative concentration of asparagine with nanoplastic exposure was dependent on fetal sex (p < 0.005). Maternal exposure to polystyrene nanoplastics caused abnormal fetal brain metabolism in mice. The present study demonstrates the potential impacts of nanoplastic exposure during fetal development and motivates further studies to evaluate the risk to human pregnancies.
Identifiants
pubmed: 37989919
doi: 10.1007/s11306-023-02061-3
pii: 10.1007/s11306-023-02061-3
doi:
Substances chimiques
Polystyrenes
0
Microplastics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
96Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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