Molecular dynamics of JUNO-IZUMO1 complexation suggests biologically relevant mechanisms in fertilization.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
received:
20
07
2023
accepted:
06
11
2023
medline:
23
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
epublish
Résumé
JUNO-IZUMO1 binding is the first known physical link created between the sperm and egg membranes in fertilization, however, how this initiates sperm-egg fusion remains elusive. As advanced structural insights will help to combat the infertility crisis, or advance fertility control, we employed all-atom Molecular Dynamics (MD) to derive dynamic structural insights that are difficult to obtain experimentally. We found that the hydrated JUNO-IZUMO1 interface is composed of a large set of short-lived non-covalent interactions. The contact interface is destabilized by strategically located point mutations, as well as by Zn
Identifiants
pubmed: 37990051
doi: 10.1038/s41598-023-46835-0
pii: 10.1038/s41598-023-46835-0
pmc: PMC10663542
doi:
Substances chimiques
Receptors, Cell Surface
0
Membrane Proteins
0
Folic Acid
935E97BOY8
Immunoglobulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20342Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 175839
Informations de copyright
© 2023. The Author(s).
Références
J Comput Chem. 2011 Jul 30;32(10):2319-27
pubmed: 21500218
Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8
pubmed: 23934049
PLoS One. 2012;7(9):e46276
pubmed: 23050004
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
pubmed: 32393636
Geburtshilfe Frauenheilkd. 2014 Sep;74(9):845-851
pubmed: 25278626
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303
pubmed: 29788355
Curr Biol. 2016 Feb 8;26(3):R100-1
pubmed: 26859261
J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90
pubmed: 22946049
J Cell Biol. 2023 Feb 6;222(2):
pubmed: 36394541
Sci Rep. 2020 Mar 24;10(1):5335
pubmed: 32210282
Nature. 2016 Jun 15;534(7608):566-9
pubmed: 27309808
PLoS Comput Biol. 2021 Jan 28;17(1):e1008667
pubmed: 33507980
Proteins. 1995 Sep;23(1):12-31
pubmed: 8539245
PLoS Biol. 2020 Nov 13;18(11):e3000953
pubmed: 33186358
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Adv Appl Bioinform Chem. 2015 Nov 19;8:37-47
pubmed: 26604800
Elife. 2021 Apr 19;10:
pubmed: 33871360
J Phys Chem B. 2021 Jul 22;125(28):7598-7612
pubmed: 34247488
Int J Mol Sci. 2014 Jun 13;15(6):10652-68
pubmed: 24933635
Elife. 2020 Jun 02;9:
pubmed: 32484434
PLoS One. 2012;7(6):e39252
pubmed: 22723976
Nature. 2005 Mar 10;434(7030):234-8
pubmed: 15759005
Antioxidants (Basel). 2021 Sep 15;10(9):
pubmed: 34573104
J Chem Inf Model. 2018 Nov 26;58(11):2178-2182
pubmed: 30351057
Electrophoresis. 2009 Jun;30 Suppl 1:S162-73
pubmed: 19517507
J Chem Phys. 2020 Jul 28;153(4):044130
pubmed: 32752662
Sci Adv. 2022 Aug 12;8(32):eabo6049
pubmed: 35960805
Curr Opin Struct Biol. 2018 Apr;49:18-26
pubmed: 29172147
Commun Biol. 2022 Apr 7;5(1):332
pubmed: 35393517
Nat Commun. 2016 Jul 15;7:12198
pubmed: 27416963
Am J Clin Nutr. 2015 Oct;102(4):943-50
pubmed: 26354529
Nature. 2013 Aug 22;500(7463):486-9
pubmed: 23851396
J Comput Chem. 2009 Jul 30;30(10):1545-614
pubmed: 19444816
Integr Biol (Camb). 2017 Feb 20;9(2):135-144
pubmed: 28102396
Nature. 2016 Jun 15;534(7608):562-5
pubmed: 27309818
Nat Struct Biol. 2002 Sep;9(9):646-52
pubmed: 12198485
Philos Trans R Soc Lond B Biol Sci. 2015 Feb 5;370(1661):20140101
pubmed: 25533103
Sci Adv. 2022 Sep 9;8(36):eabn0047
pubmed: 36070373
Biophys J. 2018 Feb 6;114(3):577-583
pubmed: 29414703
J Chem Inf Model. 2016 Dec 27;56(12):2287-2291
pubmed: 27976886
Nature. 2014 Apr 24;508(7497):483-7
pubmed: 24739963
Sci Rep. 2016 Apr 26;6:24737
pubmed: 27113677
Sci Rep. 2016 May 24;6:26536
pubmed: 27216779
J Biochem Mol Toxicol. 2021 Aug;35(8):e22823
pubmed: 34051019
Commun Biol. 2022 Sep 17;5(1):984
pubmed: 36115925
Front Cell Dev Biol. 2022 Apr 05;10:824629
pubmed: 35478965
J Mol Graph Model. 2019 Mar;87:172-184
pubmed: 30553157
FEBS Lett. 2007 May 22;581(11):2174-80
pubmed: 17328899
J Comput Aided Mol Des. 2015 Jan;29(1):23-35
pubmed: 25323390
Hum Reprod. 2017 Aug 1;32(8):1560-1573
pubmed: 28854585
Structure. 2013 Oct 8;21(10):1735-42
pubmed: 24035711
Nat Commun. 2015 Nov 16;6:8858
pubmed: 26568141
J Assist Reprod Genet. 2018 Mar;35(3):539-544
pubmed: 29243140
Am J Obstet Gynecol. 2002 Dec;187(6):1699-708
pubmed: 12501086