Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4

CD4+ T cells adaptive immunity aging immunology immunometabolism mitochondrial dysfunction

Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
21 Nov 2023
Historique:
revised: 17 09 2023
received: 05 06 2023
medline: 22 11 2023
pubmed: 22 11 2023
entrez: 22 11 2023
Statut: aheadofprint

Résumé

Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4

Identifiants

pubmed: 37990641
doi: 10.1002/advs.202303664
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2303664

Subventions

Organisme : NIA NIH HHS
Pays : United States
Organisme : NIH HHS
ID : P01AG051428
Pays : United States
Organisme : NIH HHS
ID : S10OD028653
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1T32HL098049
Pays : United States

Informations de copyright

© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Références

I. M. Orme, J. Immunol. 1987, 138, 4414.
A. N. Akbar, S. M. Henson, A. Lanna, Trends Immunol. 2016, 37, 866.
A. Donnini, F. Re, M. Bollettini, R. Moresi, S. Tesei, G. Bernardini, M. Provinciali, Biogerontology 2005, 6, 193.
J. Nikolich-Žugich, J. Immunol. 2014, 193, 2622.
R. E. Yanes, H. Zhang, Y. Shen, C. M. Weyand, J. J. Goronzy, Clin. Immunol. 2019, 207, 58.
D. K. J. Pieren, N. A. M. Smits, M. D. B. Van De Garde, T. Guichelaar, Sci. Rep. 2019, 9, 5587.
N. Mirza, K. Pollock, D. B. Hoelzinger, A. L. Dominguez, J. Lustgarten, Aging Cell 2011, 10, 853.
G. Nagy, A. Koncz, A. Perl, J. Immunol. 2003, 171, 5188.
G. Desdín-Micó, G. Soto-Heredero, M. Mittelbrunn, Mitochondrion 2018, 41, 51.
A. Perl, R. Hanczko, E. Doherty, Methods Mol Biol 2012, 900, 61.
P. Fisicaro, V. Barili, B. Montanini, G. Acerbi, M. Ferracin, F. Guerrieri, D. Salerno, C. Boni, M. Massari, M. C. Cavallo, G. Grossi, T. Giuberti, P. Lampertico, G. Missale, M. Levrero, S. Ottonello, C. Ferrari, Nat. Med. 2017, 23, 327.
G. Desdín-Micó, G. Soto-Heredero, J. F. Aranda, J. Oller, E. Carrasco, E. Gabandé-Rodríguez, E. M. Blanco, A. Alfranca, L. Cussó, M. Desco, B. Ibañez, A. R. Gortazar, P. Fernández-Marcos, M. N. Navarro, B. Hernaez, A. Alcamí, F. Baixauli, M. Mittelbrunn, Science 2020, 368, 1371.
M. M. Kamiński, S. W. Sauer, C.-D. Klemke, D. Süss, J. G. Okun, P. H. Krammer, K. Gülow, J. Immunol. 2010, 184, 4827.
V. Adam-Vizi, C. Chinopoulos, Trends Pharmacol. Sci. 2006, 27, 639.
D. B. Zorov, M. Juhaszova, S. J. Sollott, Physiol. Rev. 2014, 94, 909.
T. Gill, A. D. Levine, J. Biol. Chem. 2013, 288, 26246.
J. A. Ball, I. Vlisidou, M. D. Blunt, W. Wood, S. G. Ward, J. Immunol. 2017, 198, 3679.
E. L. Yarosz, C.-H. Chang, Immune Netw 2018, 18, e14.
A. V. Belikov, B. Schraven, L. Simeoni, J Biomed Sci 2015, 22, 85.
M. P. Murphy, Biochem. J. 2009, 417, 1.
J. J. Poderoso, Arch. Biochem. Biophys. 2009, 484, 214.
J. Dan Dunn, L. A. Alvarez, X. Zhang, T. Soldati, Redox Biol. 2015, 6, 472.
J. B. Spinelli, M. C. Haigis, Nat. Cell Biol. 2018, 20, 745.
A. De Gaetano, L. Gibellini, G. Zanini, M. Nasi, A. Cossarizza, M. Pinti, Antioxidants (Basel) 2021, 10, 794.
L. D. Osellame, T. S. Blacker, M. R. Duchen, Best Pract Res Clin Endocrinol Metab 2012, 26, 711.
A. Lanna, M. L. Dustin, Cell Res. 2016, 26, 969.
A. Czajka, S. Ajaz, L. Gnudi, C. K. Parsade, P. Jones, F. Reid, A. N. Malik, EBioMedicine 2015, 2, 499.
M. Lagouge, N.-G. Larsson, J. Intern. Med. 2013, 273, 529.
M. D. Brand, D. G. Nicholls, Biochem. J. 2011, 435, 297.
J. Suski, M. Lebiedzinska, M. Bonora, P. Pinton, J. Duszynski, M. R. Wieckowski, Methods Mol Biol 2018, 1782, 357.
E. Georgieva, Z. Zhelev, I. Aoki, R. Bakalova, T. Higashi, Anticancer Res. 2016, 36, 5273.
A. Bhargava, N. K. Khare, N. Bunkar, R. K. Lenka, P. K. Mishra, Cell Biol. Int. 2016, 40, 166.
R. Lichtenfels, D. Mougiakakos, C. C. Johansson, S. P. Dressler, C. V. Recktenwald, R. Kiessling, B. Seliger, PLoS One 2012, 7, e41345.
D. G. Franchina, C. Dostert, D. Brenner, Trends Immunol. 2018, 39, 489.
C. H. Patel, J. D. Powell, Curr. Opin. Immunol. 2017, 46, 82.
A. Agrawal, U. Mabalirajan, Am J Physiol Lung Cell Mol Physiol 2016, 310, L103.
A. E. M., Curr Protoc Stem Cell Biol Chapter 1, Unit1C 3, 2007.
M. J. Kim, J. W. Hwang, C.-K. Yun, Y. Lee, Y.-S. Choi, Sci. Rep. 2018, 8, 3330.
J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, A. Cardona, Nat. Methods 2012, 9, 676.
B. C. Searle, L. K. Pino, J. D. Egertson, Y. S. Ting, R. T. Lawrence, B. X. Maclean, J. Villén, M. J. Maccoss, Nat. Commun. 2018, 9, 5128.
G. Rosenberger, C. C. Koh, T. Guo, T. H. L. Röst, P. Kouvonen, B. C. Collins, M. Heusel, Y. Liu, E. Caron, A. Vichalkovski, M. Faini, O. T. Schubert, P. Faridi, H. A. Ebhardt, M. atondo, H. Lam, S. L. Bader, D. S. Campbell, E. W. Deutsch, R. L. Moritz, S. Tate, R. Aebersold, Sci Data. 2014, 16, 140031.
X. Sun, C. Zhang, H. Jin, G. Sun, Y. Tian, W. Shi, D. Zhang, Int. Immunopharmacol. 2016, 41, 56.
T. Burkholder, C. Foltz, E. Karlsson, C. G. Linton, J. M. Smith, Curr Protoc Mouse Biol 2012, 2, 145.
M. H. Ullman-Cullere, C. J. Foltz, Lab Anim Sci 1999, 49, 319.
G. L. Beamer, J. Cyktor, D. K. Flaherty, P. C. Stromberg, B. Carruthers, J. Turner, Eur. J. Immunol. 2012, 42, 870.
J. C. Cyktor, B. Carruthers, R. A. Kominsky, G. L. Beamer, P. Stromberg, J. Turner, J. Immunol. 2013, 190, 2778.
D. W. Huang, B. T. Sherman, R. A. Lempicki, Nat. Protoc. 2009, 4, 44.
B. T. Sherman, M. Hao, J. Qiu, X. Jiao, M. W. Baseler, H. C. Lane, T. Imamichi, W. Chang, Nucleic Acids Res. 2022, 50, W216,.
Benjamini, Y., Y. Hochberg, Journal of the Royal Statistical Society: Series B (Methodological) 1995, 57, 289.
C. W. T. Leung, Y. Hong, J. Hanske, E. Zhao, S. Chen, E. V. Pletneva, B. Z. Tang, Anal. Chem. 2014, 86, 1263.
G. Paradies, V. Paradies, V. De Benedictis, F. M. Ruggiero, G. Petrosillo, Biochim. Biophys. Acta 2014, 1837, 408.
C. Osman, D. R. Voelker, T. Langer, J. Cell Biol. 2011, 192, 7.
S. A. Mookerjee, R. L. S. Goncalves, A. A. Gerencser, D. G. Nicholls, M. D. Brand, Biochim. Biophys. Acta 2015, 1847, 171.
K. Yoshioka, M. Saito, K.-B. Oh, Y. Nemoto, H. Matsuoka, M. Natsume, H. Abe, Biosci Biotechnol Biochem 1996, 60, 1899.
W. H. Kim, J. Lee, D.-W. Jung, D. R. Williams, Sensors (Basel) 2012, 12, 5005.
M. Bonora, S. Patergnani, A. Rimessi, E. De Marchi, J. M. Suski, A. Bononi, C. Giorgi, S. Marchi, S. Missiroli, F. Poletti, M. R. Wieckowski, P. Pinton, Purinergic Signal 2012, 8, 343.
S. A. Mookerjee, A. A. Gerencser, D. G. Nicholls, M. D. Brand, J. Biol. Chem. 2017, 292, 7189.
T. R. Malek, I. Castro, Immunity 2010, 33, 153.
A. N. Shatrova, E. V. Mityushova, I. O. Vassilieva, N. D. Aksenov, V. V. Zenin, N. N. Nikolsky, I. I. Marakhova, PLoS One 2016, 11, e0167215.
J. S Lefebvre, Open Longev Sci 2012, 6, 83.
L. Haynes, S. M. Eaton, E. M. Burns, T. D. Randall, S. L. Swain, Proc Natl Acad Sci U S A 2003, 100, 15053.
M. A. Pahlavani, A. Richardson, Mech Ageing Dev 1996, 89, 125.
M. L. Thoman, W. O. Weigle, J. Immunol. 1981, 127, 2102.
L. Haynes, P.-J. Linton, S. M. Eaton, S. L. Tonkonogy, S. L. Swain, J. Exp. Med. 1999, 190, 1013.
E. M. Gardner, D. M. Murasko, Biogerontology 2002, 3, 271.
L. Simeoni, I. Bogeski, Biol. Chem. 2015, 396, 555.
P. Kesarwani, A. K. Murali, A. A. Al-Khami, S. Mehrotra, Antioxid Redox Signal 2013, 18, 1497.
L. A. Sena, S. Li, A. Jairaman, M. Prakriya, T. Ezponda, D. A. Hildeman, C.-R. Wang, P. T. Schumacker, J. D. Licht, H. Perlman, P. J. Bryce, N. S. Chandel, Immunity 2013, 38, 225.
M. G. Marko, T. Ahmed, S. C. Bunnell, D. Wu, H. Chung, B. T. Huber, S. N. Meydani, J. Immunol. 2007, 178, 1443.
D. M. Previte, J. D. Piganelli, Antioxid Redox Signal 2017.
D. M. Previte, E. C. O'connor, E. A. Novak, C. P. Martins, K. P. Mollen, J. D. Piganelli, PLoS One 2017, 12, e0175549.
A. N. Patananan, T.-H. Wu, P.-Y. Chiou, M. A. Teitell, Cell Metab. 2016, 23, 785.
A. Caicedo, et al., Stem Cells Int 2017, 2017, 7610414.
J.-C. Chang, H.-S. Chang, Y.-C. Wu, W.-L. Cheng, T.-T. Lin, H.-J. Chang, S.-J. Kuo, S.-T. Chen, C.-S. Liu, J Exp Clin Cancer Res 2019, 38, 30.
W. Chen, K. Shi, B. Chu, X. Wei, Z. Qian, Nano Lett. 2019, 19, 2905.
Y. Zhang, Z. Yu, D. Jiang, X. Liang, S. Liao, Z. Zhang, W. Yue, X. Li, S.-M. Chiu, Y.-H. Chai, Y. Liang, Y. Chow, S. Han, A. Xu, H.-F. Tse, Q. Lian, Stem Cell Rep. 2016, 7, 749.
D. Jiang, F. Gao, Y. Zhang, D. S. H. Wong, Q. Li, H.-F. Tse, G. Xu, Z. Yu, Q. Lian, Cell Death Dis. 2016, 7, e2467.
A. C. Court, A. Le-Gatt, P. Luz-Crawford, E. Parra, V. Aliaga-Tobar, L. F. Bátiz, R. A. Contreras, M. I. Ortúzar, M. Kurte, R. Elizondo-Vega, V. Maracaja-Coutinho, K. Pino-Lagos, F. E. Figueroa, M. Khoury, EMBO Rep. 2020, 21, e48052.
S. Vaena, P. Chakraborty, H. G. Lee, A. H. Janneh, M. F. Kassir, G. Beeson, Z. Hedley, A. Yalcinkaya, M. H. Sofi, H. Li, M. L. Husby, R. V. Stahelin, X.-Z. Yu, S. Mehrotra, B. Ogretmen, Cell Rep. 2021, 35, 109076.
Y. Guo, Y.-Q. Xie, M. Gao, Y. Zhao, F. Franco, M. Wenes, I. Siddiqui, A. Bevilacqua, H. Wang, H. Yang, B. Feng, X. Xie, C. M. Sabatel, B. Tschumi, A. Chaiboonchoe, Y. Wang, W. Li, W. Xiao, W. Held, P. Romero, P.-C. Ho, L. Tang, Nat. Immunol. 2021, 22, 746.
J. Kang, S. Pervaiz, Biochem. Res. Int. 2012, 2012, 896751.
R. J. Mailloux, S. L. Mcbride, M.-E. Harper, Trends Biochem. Sci. 2013, 38, 592.
E. Bertero, C. Maack, Circ. Res. 2018, 122, 1460.
M. Redza-Dutordoir, D. A. Averill-Bates, Biochim. Biophys. Acta 2016, 1863, 2977.
G. Petrosillo, F. M. Ruggiero, G. Paradies, FASEB J. 2003, 17, 2202.
N. Braidy, G. J. Guillemin, H. Mansour, T. Chan-Ling, A. Poljak, R. Grant, PLoS One 2011, 6, e19194.
B. E. Christian, G. S. Shadel, Curr. Biol. 2014, 24, R206.
P. Mishra, D. C. Chan, J. Cell Biol. 2016, 212, 379.
A. Mohanty, R. Tiwari-Pandey, N. R. Pandey, J Cell Commun Signal 2019, 13, 303.
C. M. Weyand, J. J. Goronzy, Ann Am Thorac Soc 2016, 13, S422.
D. Herndler-Brandstetter, Front Immunol 2013, 4, 296.
A. Quintana, C. Schwindling, A. S. Wenning, U. Becherer, J. Rettig, E. C. Schwarz, M. Hoth, Proc Natl Acad Sci U S A 2007, 104, 14418.
K. M. Fracchia, C. Y. Pai, C. M. Walsh, Front Immunol 2013, 4, 324.
O. Leavy, Nat. Rev. Immunol. 2016, 16, 535.
M. D. Buck, D. O'sullivan, R. I. Klein Geltink, J. D. Curtis, C.-H. Chang, D. E. Sanin, J. Qiu, O. Kretz, D. Braas, G. J. W. Van Der Windt, Q. Chen, S. C.-C. Huang, C. M. O'neill, B. T. Edelson, E. J. Pearce, H. Sesaki, T. B. Huber, A. S. Rambold, E. L. Pearce, Cell 2016, 166, 63.
S. Dimeloe, A.-V. Burgener, J. Grählert, C. Hess, Immunology 2017, 150, 35.
S. L. Sanderson, A. K. Simon, Aging Cell 2017, 16, 1234.
P. Venditti, L. Di Stefano, S. Di Meo, Mitochondrion 2013, 13, 71.
H. J. Kim, J. Lim, Y.-S. Jang, E.-C. Shin, H.-R. Kim, J.-Y. Seoh, J. S. Lee, S. N. Lee, J. L. Kang, Y.-H. Choi, Cell. Physiol. Biochem. 2017, 42, 2467.
M. Reth, Nat. Immunol. 2002, 3, 1129.
A. Rimessi, M. Previati, F. Nigro, M. R. Wieckowski, P. Pinton, Int. J. Biochem. Cell Biol. 2016, 81, 281.
M. J. Davies, Biochem. J. 2016, 473, 805.
E. L. Mills, B. Kelly, L. A. J. O'neill, Nat. Immunol. 2017, 18, 488.
G. Zsurka, V. Peeva, A. Kotlyar, W. Kunz, Genes (Basel) 2018, 9, 175.
A. S. Ziada, M. Y. Lu, J. Ignas-Menzies, E. Paintsil, M. Li, O. Ogbuagu, S. Saberi, A. Y. Y. Hsieh, B. Sattha, P. R. Harrigan, S. Kalloger, H. C. F. Côté, Aging Cell 2019, 18, e13018.
Y. Mikhed, A. Daiber, S. Steven, Int. J. Mol. Sci. 2015, 16, 15918.
P. S. Brookes, Free Radic Biol Med 2005, 38, 12.
R. Holmdahl, O. Sareila, A. Pizzolla, S. Winter, C. Hagert, N. Jaakkola, T. Kelkka, L. M. Olsson, K. Wing, L. Bäckdahl, Antioxid Redox Signal 2013, 18, 1463.
R. Jitschin, A. D. Hofmann, H. Bruns, A. Gießl, J. Bricks, J. Berger, D. Saul, M. J. Eckart, A. Mackensen, D. Mougiakakos, Blood 2014, 123, 2663.
J. Dudek, Front Cell Dev Biol 2017, 5, 90.
G. Paradies, G. Petrosillo, V. Paradies, F. M. Ruggiero, Free Radic Biol Med 2010, 48, 1286.
N. Ron-Harel, G. Notarangelo, J. M. Ghergurovich, J. A. Paulo, P. T. Sage, D. Santos, F. K. Satterstrom, S. P. Gygi, J. D. Rabinowitz, A. H. Sharpe, M. C. Haigis, Proc Natl Acad Sci U S A 2018, 115, 13347.
J. Turner, I. M. Orme, Exp. Gerontol. 2002, 37, 907.
B. Vesosky, D. K. Flaherty, J. Turner, Infect. Immun. 2006, 74, 3314.
S. Gaffen, K. Liu, Cytokine 2004, 28, 109.
A. J. Case, C. T. Roessner, J. Tian, M. C. Zimmerman, PLoS One 2016, 11, e0164609.
L. Moldovan, N. I. Moldovan, Histochem. Cell Biol. 2004, 122, 395.
D. E. Handy, J. Loscalzo, Antioxid Redox Signal 2012, 16, 1323.
C. Giorgi, F. Baldassari, A. Bononi, M. Bonora, E. De Marchi, S. Marchi, S. Missiroli, S. Patergnani, A. Rimessi, J. M. Suski, M. R. Wieckowski, P. Pinton, Cell Calcium 2012, 52, 36.
H. Zhong, M. Xiao, K. Zarkovic, M. Zhu, R. Sa, J. Lu, Y. Tao, Q. Chen, L. Xia, S. Cheng, G. Waeg, N. Zarkovic, H. Yin, Free Radic Biol Med 2017, 102, 67.
H.-J. Kim, A. E. Nel, J. Immunol. 2005, 175, 2948.
N. Ron-Harel, A. H. Sharpe, M. C. Haigis, Gerontology 2015, 61, 131.
L. Almeida, M. Lochner, L. Berod, T. Sparwasser, Semin. Immunol. 2016, 28, 514.
H. Mattoo, M. Faulkner, U. Kandpal, R. Das, V. Lewis, A. George, S. Rath, J. M. Durdik, V. Bal, Int. Immunol. 2009, 21, 1277.
G. Pattabiraman, K. Palasiewicz, J. P. Galvin, D. S. Ucker, Aging Cell 2017, 16, 585.
M. Ghatreh-Samani, N. Esmaeili, M. Soleimani, M. Asadi-Samani, K. Ghatreh-Samani, H. Shirzad, Cent. Eur. J. Immunol. 2016, 41, 116.
I. Harpaz, U. Bhattacharya, Y. Elyahu, I. Strominger, A. Monsonego, Front Immunol 2017, 8, 283.
B. Vesosky, J. Turner, Immunol Rev 2005, 205, 229.
J. Nielsen, K. D. Gejl, M. Hey-Mogensen, H.-C. Holmberg, C. Suetta, P. Krustrup, C. P. H. Elemans, N. Ørtenblad, J Physiol 2017, 595, 2839.
L. Shi, B. P. Tu, Curr. Opin. Cell Biol. 2015, 33, 125.
K. M. Quinn, R. Palchaudhuri, C. S. Palmer, N. L. La Gruta, Clin Transl Immunology 2019, 8, e01091.
S. H. Ross, D. A. Cantrell, Annu. Rev. Immunol. 2018, 36, 411.
D. Busse, M. De La Rosa, K. Hobiger, K. Thurley, M. Flossdorf, A. Scheffold, T. Höfer, Proc Natl Acad Sci U S A 2010, 107, 3058.
W. Liao, J.-X. Lin, W. J. Leonard, Immunity 2013, 38, 13.

Auteurs

Colwyn A Headley (CA)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, 43201, USA.
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Shalini Gautam (S)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Angelica Olmo-Fontanez (A)

Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Andreu Garcia-Vilanova (A)

Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Varun Dwivedi (V)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Anwari Akhter (A)

Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Alyssa Schami (A)

Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Kevin Chiem (K)

Disease Intervention & Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Russell Ault (R)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.
Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, 43201, USA.

Hao Zhang (H)

Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.

Hong Cai (H)

Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.

Alison Whigham (A)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Jennifer Delgado (J)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Amberlee Hicks (A)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Philip S Tsao (PS)

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Jonathan Gelfond (J)

UT-Health San Antonio, Department of Epidemiology & Biostatistics, San Antonio, Texas, 78229, USA.

Luis Martinez-Sobrido (L)

Disease Intervention & Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Yufeng Wang (Y)

Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249, USA.

Jordi B Torrelles (JB)

Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Joanne Turner (J)

Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA.

Classifications MeSH