Differential patterns in runs of homozygosity in two mice lines under divergent selection for environmental variability for birth weight.
divergent selection
environmental birth weight variability
molecular inbreeding
runs of homozygosity
Journal
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
ISSN: 1439-0388
Titre abrégé: J Anim Breed Genet
Pays: Germany
ID NLM: 100955807
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
revised:
11
09
2023
received:
24
05
2023
accepted:
09
11
2023
medline:
22
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
aheadofprint
Résumé
Runs of homozygosity (ROH) are defined as long continuous homozygous stretches in the genome which are assumed to originate from a common ancestor. It has been demonstrated that divergent selection for variability in mice is possible and that low variability in birth weight is associated with robustness. To analyse ROH patterns and ROH-based genomic inbreeding, two mouse lines that were divergently selected for birth weight variability for 26 generations were used, with: 752 individuals for the high variability line (H-Line), 766 individuals for the low variability line (L-Line) and 74 individuals as a reference population. Individuals were genotyped using the high density Affymetrix Mouse Diversity Genotyping Array. ROH were identified using both the sliding windows (SW) and the consecutive runs (CR) methods. Inbreeding coefficients were calculated based on pedigree (F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science, Innovation, and Universities
ID : PGC2018-096198-A-I00
Informations de copyright
© 2023 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd.
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