Modeling familial and sporadic Parkinson's disease in small fishes.
Nothobranchius furzeri
Parkinson's disease
medaka
zebrafish
Journal
Development, growth & differentiation
ISSN: 1440-169X
Titre abrégé: Dev Growth Differ
Pays: Japan
ID NLM: 0356504
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
revised:
26
10
2023
received:
01
09
2023
accepted:
16
11
2023
pubmed:
22
11
2023
medline:
22
11
2023
entrez:
22
11
2023
Statut:
aheadofprint
Résumé
The establishment of animal models for Parkinson's disease (PD) has been challenging. Nevertheless, once established, they will serve as valuable tools for elucidating the causes and pathogenesis of PD, as well as for developing new strategies for its treatment. Following the recent discovery of a series of PD causative genes in familial cases, teleost fishes, including zebrafish and medaka, have often been used to establish genetic PD models because of their ease of breeding and gene manipulation, as well as the high conservation of gene orthologs. Some of the fish lines can recapitulate PD phenotypes, which are often more pronounced than those in rodent genetic models. In addition, a new experimental teleost fish, turquoise killifish, can be used as a sporadic PD model, because it spontaneously manifests age-dependent PD phenotypes. Several PD fish models have already made significant contributions to the discovery of novel PD pathological features, such as cytosolic leakage of mitochondrial DNA and pathogenic phosphorylation in α-synuclein. Therefore, utilizing various PD fish models with distinct degenerative phenotypes will be an effective strategy for identifying emerging facets of PD pathogenesis and therapeutic modalities.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19gm6110028; JP23gm1710010
Organisme : Japan Society for the Promotion of Science
ID : KAKENHI JP 21K19458 T.Y.
Organisme : Japan Society for the Promotion of Science
ID : JP 18H02723 T.Y.
Organisme : Japan Society for the Promotion of Science
ID : KAKENHI JP 22484842 H.M.
Organisme : Japan Society for the Promotion of Science
ID : JP 23790744 H.M.
Organisme : Ministry of Education, Culture, Sports, Science and Technology - 21st Century Brodmann Areas Mapping Integrating Molecular and Functional Information
Organisme : Moonshot Research and Development Program
ID : JPMJMS2024
Organisme : NAGAI Foundation for Science and Technology
Organisme : Takeda Science Foundation
Organisme : Tokyo Biochemical Research Foundation
Organisme : Uehara Memorial Foundation
Informations de copyright
© 2023 Japanese Society of Developmental Biologists.
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