Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease Drug delivery Lung cancer Nanoparticles Nucleic acid therapeutics Phytoceuticals miRNA

Journal

Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264

Informations de publication

Date de publication:
22 Nov 2023
Historique:
received: 13 08 2023
accepted: 30 10 2023
medline: 22 11 2023
pubmed: 22 11 2023
entrez: 22 11 2023
Statut: aheadofprint

Résumé

Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties. This picture was generated with BioRender.

Identifiants

pubmed: 37991539
doi: 10.1007/s00210-023-02830-w
pii: 10.1007/s00210-023-02830-w
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Gabriele De Rubis (G)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Keshav Raj Paudel (KR)

Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, 2007, Australia.

Leander Corrie (L)

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.

Samir Mehndiratta (S)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Vyoma K Patel (VK)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.

Popat S Kumbhar (PS)

Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra, 416113, India.

Arehalli Sidramappa Manjappa (AS)

Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra, 416113, India.
Department of Pharmaceutics, Vasantidevi Patil Institute of Pharmacy, Kodoli, Kolkapur, Maharashtra, 416114, India.

John Disouza (J)

Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra, 416113, India.

Vandana Patravale (V)

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, Maharashtra, India.

Gaurav Gupta (G)

Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Chennai, India.
School of Pharmacy, Graphic Era Hill University, Dehradun, 248007, India.
School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, 302017, India.

Bikash Manandhar (B)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Rashi Rajput (R)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Alexandra Kailie Robinson (AK)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Ruby-Jean Reyes (RJ)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

Amlan Chakraborty (A)

Division of Immunology, Immunity to Infection and Respiratory Medicine (DIIIRM), School of Biological Sciences I Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Dinesh Kumar Chellappan (DK)

School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.

Sachin Kumar Singh (SK)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.

Brian Gregory George Oliver (BGG)

School of Life Sciences, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, Australia.

Philip Michael Hansbro (PM)

Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, 2007, Australia.

Kamal Dua (K)

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia. kamal.dua@uts.edu.au.
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia. kamal.dua@uts.edu.au.

Classifications MeSH