Author instructions in biomedical journals infrequently address systematic review reporting and methodology: a cross-sectional study.

We aimed to analyse how instructions for authors in journals indexed in MEDLINE address systematic review (SR) reporting and methodology. We analyzed instructions for authors in 20% of MEDLINE-indexed journals listed in the online catalogue of the National Library of Medicine (NLM) on July 27, 2021. We extracted data only from the instructions published in English. We extracted data on the existence of instructions for reporting and methodology of SRs. Instructions from 1237 journals mentioned SRs in 45% (n=560) of the cases. SR registration was mentioned in 104/1237 (8%) of instructions. Guidelines for reporting SR protocols were found in 155/1237 (13%) of instructions. Guidelines for reporting SRs were explicitly mentioned in 461/1237 (37%), whereas the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network was referred to in 474/1237 (38%) of instructions. Less than 2% (n=20) of instructions mentioned risk of bias and meta-analyses; less than 1% mentioned certainty of evidence assessment, methodological expectations, updating of SRs, overviews of SRs or scoping reviews. Journals indexed in MEDLINE rarely provide instructions for authors regarding SR reporting and methodology. Such instructions could potentially raise authors' awareness and improve how SRs are prepared and reported.

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