The dopamine hypothesis of autism spectrum disorder: A comprehensive analysis of the evidence.
Antipsychotics
Autism spectrum disorder
Brain organoids
Dopamine
Hypothesis
Mesocorticolimbic
Midbrain
Neuroimaging
Nigrostriatal
Oxytocin
Journal
International review of neurobiology
ISSN: 2162-5514
Titre abrégé: Int Rev Neurobiol
Pays: United States
ID NLM: 0374740
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
27
11
2023
pubmed:
23
11
2023
entrez:
22
11
2023
Statut:
ppublish
Résumé
Despite intensive research into the etiopathogenesis of autism spectrum disorder (ASD), limited progress has been achieved so far. Among the plethora of models seeking to clarify how ASD arises, a coherent dopaminergic model was lacking until recently. In 2017, we provided a theoretical framework that we designated "the dopamine hypothesis of ASD". In the meantime, numerous studies yielded empirical evidence for this model. 4 years later, we provided a second version encompassing a refined and reconceptualized framework that accounted for these novel findings. In this chapter, we will review the evidence backing the previous versions of our model and add the most recent developments to the picture. Along these lines, we intend to lay out a comprehensive analysis of the supporting evidence for the dopamine hypothesis of ASD.
Identifiants
pubmed: 37993174
pii: S0074-7742(23)00086-7
doi: 10.1016/bs.irn.2023.08.009
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-42Informations de copyright
Copyright © 2023. Published by Elsevier Inc.