Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome.
Astrocytes
Cortex
Fragile X Syndrome
Hippocampus
Neurodevelopment
Journal
International review of neurobiology
ISSN: 2162-5514
Titre abrégé: Int Rev Neurobiol
Pays: United States
ID NLM: 0374740
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
24
11
2023
pubmed:
23
11
2023
entrez:
22
11
2023
Statut:
ppublish
Résumé
Astrocytes are highly involved in a multitude of developmental processes that are known to be dysregulated in Fragile X Syndrome. Here, we examine these processes individually and review the roles astrocytes play in contributing to the pathology of this syndrome. As a growing area of interest in the field, new and exciting insight is continually emerging. Understanding these glial-mediated roles is imperative for elucidating the underlying molecular mechanisms at play, not only in Fragile X Syndrome, but also other ASD-related disorders. Understanding these roles will be central to the future development of effective, clinically-relevant treatments of these disorders.
Identifiants
pubmed: 37993178
pii: S0074-7742(23)00082-X
doi: 10.1016/bs.irn.2023.08.005
pii:
doi:
Substances chimiques
Fragile X Mental Retardation Protein
139135-51-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-215Informations de copyright
Copyright © 2023. Published by Elsevier Inc.