Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
11
04
2023
accepted:
13
09
2023
medline:
1
12
2023
pubmed:
23
11
2023
entrez:
22
11
2023
Statut:
ppublish
Résumé
HIV-1 envelope (Env) exhibits distinct conformational changes in response to host receptor (CD4) engagement. Env, a trimer of gp120 and gp41 heterodimers, has been structurally characterized in a closed, prefusion conformation with closely associated gp120s and coreceptor binding sites on gp120 V3 hidden by V1V2 loops
Identifiants
pubmed: 37993719
doi: 10.1038/s41586-023-06639-8
pii: 10.1038/s41586-023-06639-8
pmc: PMC10686819
doi:
Substances chimiques
CD4 Antigens
0
HIV Envelope Protein gp120
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1017-1025Subventions
Organisme : Bill & Melinda Gates Foundation
ID : INV-002143
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI100148
Pays : United States
Informations de copyright
© 2023. The Author(s).
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