Brush-Like Coatings Provide a Cloak of Invisibility to Titanium Implants.
antifouling surfaces
bacteria repellency
biocompatibility
brushes
stealth coatings
titanium implants
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
revised:
19
11
2023
received:
23
09
2023
pubmed:
23
11
2023
medline:
23
11
2023
entrez:
23
11
2023
Statut:
aheadofprint
Résumé
Orthopedic implants such as knee and hip implants are one of the most important types of medical devices. Currently, the surface of the most advanced implants consists of titanium or titanium-alloys with high porosity at the bone-contacting surface leading to superior mechanical properties, excellent biocompatibility, and the capability of inducing osseointegration. However, the increased surface area of porous titanium provides a nidus for bacteria colonization leading to implant-related infections, one of the main reasons for implant failure. Here, two readily applicable titanium-coatings based on hydrophilic carboxybetaine polymers that turn the surface stealth thereby preventing bacterial adhesion and colonization are developed. These coatings are biocompatible, do not affect cell functionality, exhibit great antifouling properties, and do not cause additional inflammation during the healing process. In this way, the coatings can prevent implant-related infections, while at the same time being completely innocuous to its biological environment. Thus, these coating strategies are a promising route to enhance the biocompatibility of orthopedic implants and have a high potential for clinical use, while being easy to implement in the implant manufacturing process.
Identifiants
pubmed: 37994518
doi: 10.1002/mabi.202300434
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300434Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 02P20E141
Organisme : Horizon 2020 Framework Programme
ID : 814495-2
Informations de copyright
© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
Références
J. A. Singh, S. Yu, L. Chen, J. D. Cleveland, J. Rheumatol. 2019, 46, 1134.
https://www.medgadget.com/2019/07/medical-implants-market-analysis-from-2019-to-2023-global-size-growth-share-trends-statistics-key-players-and-regional-forecast-to-2023.html, (accessed: March 2022).
K. D. Miller, L. Nogueira, A. B. Mariotto, J. H. Rowland, K. R. Yabroff, C. M. Alfano, A. Jemal, J. L. Kramer, R. L. Siegel, Ca-Cancer J. Clin. 2019, 69, 363.
R. Van Noort, J. Mater. Sci. 1987, 22, 3801.
M.-A. Malahias, L. Kostretzis, A. Greenberg, V. S. Nikolaou, A. Atrey, P. K. Sculco, J. Arthroplasty 2020, 35, 1737.
Q. Han, C. Wang, H. Chen, X. Zhao, J. Wang, ACS Biomater. Sci. Eng. 2019, 5, 5798.
I. D. Learmonth, C. Young, C. Rorabeck, Lancet 2007, 370, 1508.
S. Duman, I. Çamurcu, H. Uçpunar, A. Sevencan, S. Akinci, V. Sahin, Arch. Med. Sci. 2021, 17, 382.
N. A. Hodges, E. M. Sussman, J. P. Stegemann, Biomaterials 2021, 278, 121127.
S. Veerachamy, T. Yarlagadda, G. Manivasagam, P. K. Yarlagadda, Proc. Inst. Mech. Eng., Part H 2014, 228, 1083.
C. R. Arciola, D. Campoccia, L. Montanaro, Nat. Rev. Microbiol. 2018, 16, 397.
M. Ask, J. Lausmaa, B. Kasemo, Appl. Surf. Sci. 1989, 35, 283.
P. Tengvall, I. Lundström, Clin. Mater. 1992, 9, 115.
A. Shahid, B. Aslam, S. Muzammil, N. Aslam, M. Shahid, A. Almatroudi, K. S. Allemailem, M. Saqalein, M. A. Nisar, M. H. Rasool, J. Appl. Biomater. Funct. Mater. 2021, 19, 22808000211040304.
M. Croes, S. Bakhshandeh, I. A. J. Van Hengel, K. Lietaert, K. P. M. Van Kessel, B. Pouran, B. C. H. Van Der Wal, H. C. Vogely, W. Van Hecke, A. C. Fluit, C. H. E. Boel, J. Alblas, A. A. Zadpoor, H. Weinans, S. Amin Yavari, Acta Biomater. 2018, 81, 315.
M. T. Bernards, G. Cheng, Z. Zhang, S. Chen, S. Jiang, Macromolecules 2008, 41, 4216.
C. Rodriguez Emmenegger, E. Brynda, T. Riedel, Z. Sedlakova, M. Houska, A. B. Alles, Langmuir 2009, 25, 6328.
C. Rodriguez-Emmenegger, E. Brynda, T. Riedel, M. Houska, V. Subr, A. B. Alles, E. Hasan, J. E. Gautrot, W. T. S. Huck, Macromol. Rapid Commun. 2011, 32, 952.
F. Obstals, L. Witzdam, M. Garay-Sarmiento, N. Y.u. Kostina, J. Quandt, R. Rossaint, S. Singh, O. Grottke, C. Rodriguez-Emmenegger, ACS Appl. Mater. Interfaces 2021, 13, 11696.
Y. Inoue, T. Nakanishi, K. Ishihara, Langmuir 2013, 29, 10752.
C. Rodriguez-Emmenegger, S. Janel, A. De Los Santos Pereira, M. Bruns, F. Lafont, Polym. Chem. 2015, 6, 5740.
B. Lopez-Mila, P. Alves, T. S. Riedel, B. Dittrich, F. Mergulhão, C. Rodriguez-Emmenegger, Bioinspir. Biomim. 2018, 13, 065001.
M. V. Vasylyev, E. J. Wachtel, R. Popovitz-Biro, R. Neumann, Chemistry 2006, 12, 3507.
L. Jiang, G. Jin, J. Kang, L. Yu, W. Yoon, M. Lim, I. Par K, M. Lee, D. Jin, J. Wuhan Univ. Technol., Mater. Sci. Ed. 2014, 29, 197.
S. Dedisch, F. Obstals, A. De Los Santos Pereira, M. Bruns, F. Jakob, U. Schwaneberg, C. Rodriguez-Emmenegger, Adv. Mater. Interfaces 2019, 6, 1900847.
D. Söder, M. Garay-Sarmiento, K. Rahimi, F. Obstals, S. Dedisch, T. Haraszti, M. D. Davari, F. Jakob, C. Heß, U. Schwaneberg, C. Rodriguez-Emmenegger, Macromol. Biosci. 2021, 21, 2100158.
M. Garay-Sarmiento, L. Witzdam, M. Vorobii, C. Simons, N. Herrmann, A. De Los Santos Pereira, E. Heine, I. El-Awaad, R. Lütticken, F. Jakob, U. Schwaneberg, C. Rodriguez-Emmenegger, Adv. Funct. Mater. 2022, 32, 2106656.
L. Witzdam, Y. L. Meurer, M. Garay-Sarmiento, M. Vorobii, D. Söder, J. Quandt, T. Haraszti, C. Rodriguez-Emmenegger, Macromol. Biosci. 2022, 22, 2200025.
R. Toomey, D. Freidank, J. Rühe, Macromolecules 2004, 37, 882.
O. Prucker, T. Brandstetter, J. Rühe, Biointerphases 2018, 13, 010801.
T. Matsuda, T. Sugawara, J. Biomed. Mater. Res. 1995, 29, 749.
Â. Serrano, S. Zürcher, S. Tosatti, N. D. Spencer, Macromol. Rapid Commun. 2016, 37, 622.
S. K. Christensen, M. C. Chiappelli, R. C. Hayward, Macromolecules 2012, 45, 5237.
K. Schuh, O. Prucker, J. Rühe, Adv. Funct. Mater. 2013, 23, 6019.
J.-L. Wang, J. P. Toscano, M. S. Platz, V. Nikolaev, V. Popik, J. Am. Chem. Soc. 1995, 117, 5477.
Y. Cai, X. Wang, C. K. Poh, H. C. Tan, M. T. Soe, S. Zhang, W. Wang, Colloids Surf. B 2014, 116, 681.
N. Y. Kostina, O. Pop-Georgievski, M. Bachmann, N. Neykova, M. Bruns, J. Michálek, M. Bastmeyer, C. Rodriguez-Emmenegger, Macromol. Biosci. 2016, 16, 83.
B. Levine, Adv. Eng. Mater. 2008, 10, 788.
J. M. Anderson, A. Rodriguez, D. T. Chang, Semin. Immunol. 2008, 20, 86.
D. W. Grainger, Nat. Biotechnol. 2013, 31, 507.
N. Noskovicova, B. Hinz, P. Pakshir, Cells 2021, 10, 1794.
L. Crémet, A. Broquet, B. Brulin, C. Jacqueline, S. Dauvergne, R. Brion, K. Asehnoune, S. Corvec, D. Heymann, N. Caroff, Pathog. Dis. 2015, 73, ftv065.
B. Zmistowski, C. J. Fedorka, E. Sheehan, G. Deirmengian, M. S. Austin, J. Parvizi, J. Arthroplasty 2011, 26, 104.
D. Rodríguez-Pardo, C. Pigrau, J. Lora-Tamayo, A. Soriano, M. D. Del Toro, J. Cobo, J. Palomino, G. Euba, M. Riera, M. Sánchez-Somolinos, N. Benito, M. Fernández-Sampedro, L. Sorli, L. Guio, J. A. Iribarren, J. M. Baraia-Etxaburu, A. Ramos, A. Bahamonde, X. Flores-Sánchez, P. S. Corona, J. Ariza, Clin. Microbiol. Infect. 2014, 20, O911.