Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges.
germ cell tumour
haematological malignancy
isochromosome 12p
mediastinum
somatic-type malignancy
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
12
10
2023
received:
12
07
2023
accepted:
20
10
2023
pubmed:
23
11
2023
medline:
23
11
2023
entrez:
23
11
2023
Statut:
ppublish
Résumé
This article will review current aspects of the histopathological, immunohistochemical and molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their aetiological, epidemiological, clinical and therapeutic features. PMGCTs represent an important differential diagnosis in the spectrum of mediastinal tumours, and their diagnosis is usually made on small tissue samples from core needle biopsies in combination with diagnostic imaging and serum tumour markers. As in lymphomas, a small biopsy is often the only viable tumour sample available from these patients, as they receive chemotherapy prior to eventual surgical resection. Pathologists therefore need to apply an efficient combination of immunohistochemical markers to confirm the diagnosis of a PMGCT and to exclude morphological mimics.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-237Subventions
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.3
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.2
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.1
Informations de copyright
© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.
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