Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children.

Child Humans Retrospective Studies Iohexol Critical Illness / therapy Kidney Function Tests Glomerular Filtration Rate Creatinine
Augmented renal clearance Children Glomerular filtration rate Intensive care Kidney function

Journal

Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728

Informations de publication

Date de publication:
May 2024
Historique:
received: 19 06 2023
accepted: 26 10 2023
revised: 26 10 2023
medline: 18 3 2024
pubmed: 23 11 2023
entrez: 23 11 2023
Statut: ppublish

Résumé

Augmented renal clearance (ARC) holds a risk of subtherapeutic drug concentrations. Knowledge of patient-, disease-, and therapy-related factors associated with ARC would allow predicting which patients would benefit from intensified dosing regimens. This study aimed to identify ARC predictors and to describe ARC time-course in critically ill children, using iohexol plasma clearance (CL This is a retrospective analysis of data from the "IOHEXOL" study which validated GFR estimating formulas (eGFR) against CL Eighty-five patients were included; 57% were postoperative patients. Median CL Our findings raise PICU clinician awareness about increased risk for ARC after major surgery and in patients with eGFR above age-specific thresholds. This knowledge enables identification of patients with an ARC risk profile who would potentially benefit from a dose increase at initiation of treatment to avoid underexposure. ClinicalTrials.gov NCT05179564, registered retrospectively on January 5, 2022.

Sections du résumé

BACKGROUND BACKGROUND
Augmented renal clearance (ARC) holds a risk of subtherapeutic drug concentrations. Knowledge of patient-, disease-, and therapy-related factors associated with ARC would allow predicting which patients would benefit from intensified dosing regimens. This study aimed to identify ARC predictors and to describe ARC time-course in critically ill children, using iohexol plasma clearance (CL
METHODS METHODS
This is a retrospective analysis of data from the "IOHEXOL" study which validated GFR estimating formulas (eGFR) against CL
RESULTS RESULTS
Eighty-five patients were included; 57% were postoperative patients. Median CL
CONCLUSIONS CONCLUSIONS
Our findings raise PICU clinician awareness about increased risk for ARC after major surgery and in patients with eGFR above age-specific thresholds. This knowledge enables identification of patients with an ARC risk profile who would potentially benefit from a dose increase at initiation of treatment to avoid underexposure.
TRIAL REGISTRATION BACKGROUND
ClinicalTrials.gov NCT05179564, registered retrospectively on January 5, 2022.

Identifiants

DOI: 10.1007/s00467-023-06221-4 PMID: 37994980
pubmed: 37994980
doi: 10.1007/s00467-023-06221-4
pii: 10.1007/s00467-023-06221-4
doi:

Substances chimiques

Iohexol 4419T9MX03
Creatinine AYI8EX34EU

Banques de données

ClinicalTrials.gov
['NCT05179564']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1607-1616

Subventions

Organisme : Trasher Research Fund
ID : 15174
Organisme : Research Foundation Flanders
ID : 1881020N

Informations de copyright

© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.

Références

Rhoney DH, Metzger SA, Nelson NR (2021) Scoping review of augmented renal clearance in critically ill pediatric patients. Pharmacotherapy 41:851–863
pubmed: 34431121 doi: 10.1002/phar.2617
Dhont E, Van Der Heggen T, De Jaeger A, Vande Walle J, De Paepe P, De Cock PA (2020) Augmented renal clearance in pediatric intensive care: are we undertreating our sickest patients? Pediatr Nephrol 35:25–39
pubmed: 30374606 doi: 10.1007/s00467-018-4120-2
Udy AA, Baptista JP, Lim NL, Joynt GM, Jarrett P, Wockner L, Boots RJ, Lipman J (2014) Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations. Crit Care Med 42:520–527
pubmed: 24201175 doi: 10.1097/CCM.0000000000000029
De Cock PA, Standing JF, Barker CI, de Jaeger A, Dhont E, Carlier M, Verstraete AG, Delanghe JR, Robays H, De Paepe P (2015) Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children. Antimicrob Agents Chemother 59:7027–7035
pubmed: 26349821 pmcid: 4604416 doi: 10.1128/AAC.01368-15
Avedissian SN, Rhodes NJ, Kim Y, Bradley J, Valdez JL, Le J (2020) Augmented renal clearance of aminoglycosides using population-based pharmacokinetic modelling with Bayesian estimation in the paediatric ICU. J Antimicrob Chemother 75:162–169
pubmed: 31648297
Van Der Heggen T, Dhont E, Willems J, Herck I, Delanghe JR, Stove V, Verstraete AG, Vanhaesebrouck S, De Paepe P, De Cock P (2022) Suboptimal beta-lactam therapy in critically ill children: risk factors and outcome. Pediatr Crit Care Med 23:e309–e318
pubmed: 35426861 doi: 10.1097/PCC.0000000000002951
Scully PT, Lam WM, Coronado Munoz AJ, Modem VM (2022) Augmented renal clearance of vancomycin in suspected sepsis: single-center, retrospective pediatric cohort. Pediatr Crit Care Med 23:444–452
pubmed: 35190502 doi: 10.1097/PCC.0000000000002918
Van Der Heggen T, Dhont E, Peperstraete H, Delanghe JR, Vande Walle J, De Paepe P, De Cock PA (2019) Augmented renal clearance: a common condition in critically ill children. Pediatr Nephrol 34:1099–1106
pubmed: 30778827 doi: 10.1007/s00467-019-04205-x
Baptista JP, Neves M, Rodrigues L, Teixeira L, Pinho J, Pimentel J (2014) Accuracy of the estimation of glomerular filtration rate within a population of critically ill patients. J Nephrol 27:403–410
pubmed: 24446348 doi: 10.1007/s40620-013-0036-x
André P, Chtioui H, Dao K, Rothuizen LE, Di Paolo ER, Diezi M, Crisinel PA, Cachat F, Chehade H, Buclin T (2023) Estimating glomerular filtration rate from serum creatinine concentration in children with augmented renal clearance: all formulas are equivocal, but some are more equivocal than others. Kidney Int 103:225–226
pubmed: 36603971 doi: 10.1016/j.kint.2022.10.015
Dhont E, Windels C, Snauwaert E, Van Der Heggen T, de Jaeger A, Dhondt L, Delanghe J, Croubels S, Walle JV, De Paepe P, De Cock PA (2022) Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children. Eur J Pediatr 181:3851–3866
pubmed: 36053381 doi: 10.1007/s00431-022-04570-0
Dixon JJ, Lane K, Dalton RN, Turner C, MacPhee IAM, Chis Ster I, Philips BJ (2018) Continuous infusion of low-dose iohexol measures changing glomerular filtration rate in critically ill patients. Crit Care Med 46:e190–e197
pubmed: 29194145 doi: 10.1097/CCM.0000000000002870
Erley CM, Bader BD, Berger ED, Vochazer A, Jorzik JJ, Dietz K, Risler T (2001) Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients. Crit Care Med 29:1544–1550
pubmed: 11505124 doi: 10.1097/00003246-200108000-00008
Salmon Gandonniere C, Helms J, Le Tilly O, Benz-de Bretagne I, Bretagnol A, Bodet-Contentin L, Mercier E, Halimi JM, Benzekri-Lefevre D, Meziani F, Barin-Le Guellec C, Ehrmann S, Clinical research in intensive care and sepsis - TRIal group for global evaluation and research in SEPsis (CRICS-TriggerSep) network (2019) glomerular hyper- and hypofiltration during acute circulatory failure: iohexol-based gold-standard descriptive study. Crit Care Med 47:e623–e629
pubmed: 31306257 doi: 10.1097/CCM.0000000000003804
Sangla F, Marti PE, Verissimo T, Pugin J, de Seigneux S, Legouis D (2020) Measured and estimated glomerular filtration rate in the ICU: a prospective study. Crit Care Med 48:e1232–e1241
pubmed: 33044285 doi: 10.1097/CCM.0000000000004650
Smeets NJL, Teunissen EMM, van der Velden K, van der Burgh MJP, Linders DE, Teesselink E, Moes DAR, Tøndel C, Ter Heine R, van Heijst A, Schreuder MF, de Wildt SN (2023) Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements. Pediatr Nephrol 38:1087–1097
pubmed: 35916956 doi: 10.1007/s00467-022-05651-w
Bilbao-Meseguer I, Rodriguez-Gascon A, Barrasa H, Isla A, Solinis MA (2018) Augmented renal clearance in critically ill patients: a systematic review. Clin Pharmacokinet 57:1107–1121
pubmed: 29441476 doi: 10.1007/s40262-018-0636-7
Udy AA, Roberts JA, Shorr AF, Boots RJ, Lipman J (2013) Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients. Crit Care 17:R35
pubmed: 23448570 pmcid: 4056783 doi: 10.1186/cc12544
Barletta JF, Mangram AJ, Byrne M, Sucher JF, Hollingworth AK, Ali-Osman FR, Shirah GR, Haley M, Dzandu JK (2017) Identifying augmented renal clearance in trauma patients: validation of the augmented renal clearance in trauma intensive care scoring system. J Trauma Acute Care Surg 82:665–671
pubmed: 28129261 doi: 10.1097/TA.0000000000001387
Hefny F, Stuart A, Kung JY, Mahmoud SH (2022) Prevalence and risk factors of augmented renal clearance: a systematic review and meta-analysis. Pharmaceutics 14(2):445
pubmed: 35214177 pmcid: 8878755 doi: 10.3390/pharmaceutics14020445
Hirai K, Ihara S, Kinae A, Ikegaya K, Suzuki M, Hirano K, Itoh K (2016) Augmented renal clearance in pediatric patients with febrile neutropenia associated with vancomycin clearance. Ther Drug Monit 38:393–397
pubmed: 27172381 doi: 10.1097/FTD.0000000000000270
Lee B, Kim J, Park JD, Kang HM, Cho YS, Kim KS (2017) Predicting augmented renal clearance using estimated glomerular filtration rate in critically ill children. Clin Nephrol 88:148–155
pubmed: 28699888 doi: 10.5414/CN109216
Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N (2017) The Canadian laboratory initiative on pediatric reference intervals: a CALIPER white paper. Crit Rev Clin Lab Sci 54:358–413
pubmed: 29017389 doi: 10.1080/10408363.2017.1379945
Pottel H, Vrydags N, Mahieu B, Vandewynckele E, Croes K, Martens F (2008) Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods. Clin Chim Acta 396:49–55
pubmed: 18621041 doi: 10.1016/j.cca.2008.06.017
Ceriotti F, Boyd JC, Klein G, Henny J, Queraltó J, Kairisto V, Panteghini M (2008) Reference intervals for serum creatinine concentrations: assessment of available data for global application. Clin Chem 54:559–566
pubmed: 18202155 doi: 10.1373/clinchem.2007.099648
Dhondt L, Croubels S, De Cock P, De Paepe P, De Baere S, Devreese M (2019) Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma. J Chromatogr B Analyt Technol Biomed Life Sci 1117:77–85
pubmed: 31004849 doi: 10.1016/j.jchromb.2019.04.017
Du Bois D, Du Bois EF (1989) A formula to estimate the approximate surface area if height and weight be known. 1916. Nutrition 5:303–311 (discussion 312-303)
pubmed: 2520314
Piepsz A, Tondeur M, Ham H (2006) Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children. Eur J Nucl Med Mol Imaging 33:1477–1482
pubmed: 16865393 doi: 10.1007/s00259-006-0179-2
Pierce CB, Muñoz A, Ng DK, Warady BA, Furth SL, Schwartz GJ (2021) Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney Int 99:948–956
pubmed: 33301749 doi: 10.1016/j.kint.2020.10.047
Dhont E, Vanderheggen T, Decock PA (2022) Reply to commenting letter for “Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children” by Smeets et al. Eur J Pediatr 181:4229–4230
pubmed: 36344705 doi: 10.1007/s00431-022-04658-7
Cies J, Betancourt N, Bar A, Moore W, Chopra A (2020) 1430: Augmented renal clearance in the pediatric intensive care unit. Crit Care Med 48:692
doi: 10.1097/01.ccm.0000645636.78099.d2
Abdel El Naeem HEM, Abdelhamid MHE, Atteya DAM (2017) Impact of augmented renal clearance on enoxaparin therapy in critically ill patients. Egypt J Anaesth 33:113–117
doi: 10.1016/j.egja.2016.11.001
Barletta JF, Mangram AJ, Byrne M, Hollingworth AK, Sucher JF, Ali-Osman FR, Shirah GR, Dzandu JK (2016) The importance of empiric antibiotic dosing in critically ill trauma patients: are we under-dosing based on augmented renal clearance and inaccurate renal clearance estimates? J Trauma Acute Care Surg 81:1115–1121
pubmed: 27533906 doi: 10.1097/TA.0000000000001211
Lin Wu FL, Liu SS, Yang TY, Win MF, Lin SW, Huang CF, Wang KC, Shen LJ (2015) A larger dose of vancomycin is required in adult neurosurgical intensive care unit patients due to augmented clearance. Ther Drug Monit 37:609–618
pubmed: 25627406 doi: 10.1097/FTD.0000000000000187
Akers KS, Niece KL, Chung KK, Cannon JW, Cota JM, Murray CK (2014) Modified augmented renal clearance score predicts rapid piperacillin and tazobactam clearance in critically ill surgery and trauma patients. J Trauma Acute Care Surg 77:S163-170
pubmed: 24770557 doi: 10.1097/TA.0000000000000191
Park SK, Hur M, Kim E, Kim WH, Park JB, Kim Y, Yang JH, Jun TG, Kim CS (2016) Risk factors for acute kidney injury after congenital cardiac surgery in infants and children: a retrospective observational study. Plos One 11:e0166328
pubmed: 27832187 pmcid: 5104485 doi: 10.1371/journal.pone.0166328
Bellomo R, Auriemma S, Fabbri A, D’Onofrio A, Katz N, McCullough PA, Ricci Z, Shaw A, Ronco C (2008) The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI). Int J Artif Organs 31:166–178
pubmed: 18311733 doi: 10.1177/039139880803100210
Pottel H, Adebayo OC, Nkoy AB, Delanaye P (2023) Glomerular hyperfiltration: part 1 - defining the threshold - is the sky the limit? Pediatr Nephrol 38:2523–2527
pubmed: 36459244 doi: 10.1007/s00467-022-05827-4
Gijsen M, Huang CY, Flechet M, Van Daele R, Declercq P, Debaveye Y, Meersseman P, Meyfroidt G, Wauters J, Spriet I (2020) Development and external validation of an online clinical prediction model for augmented renal clearance in adult mixed critically ill patients: the augmented renal clearance predictor. Crit Care Med 48:e1260–e1268
pubmed: 33048900 doi: 10.1097/CCM.0000000000004667
Egea A, Dupuis C, de Montmollin E, Wicky PH, Patrier J, Jaquet P, Lefèvre L, Sinnah F, Marzouk M, Sonneville R, Bouadma L, Souweine B, Timsit JF (2022) Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study. Ann Intensive Care 12:88
pubmed: 36156744 pmcid: 9510087 doi: 10.1186/s13613-022-01058-w
Fuster-Lluch O, Geronimo-Pardo M, Peyro-Garcia R, Lizan-Garcia M (2008) Glomerular hyperfiltration and albuminuria in critically ill patients. Anaesth Intensive Care 36:674–680
pubmed: 18853585 doi: 10.1177/0310057X0803600507
De Waele JJ, Dumoulin A, Janssen A, Hoste EA (2015) Epidemiology of augmented renal clearance in mixed ICU patients. Minerva Anestesiol 81:1079–1085
pubmed: 25697881

Auteurs

Evelyn Dhont (E)

Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium. evelyn.dhont@uzgent.be.
Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. evelyn.dhont@uzgent.be.
Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. evelyn.dhont@uzgent.be.
ORCID: 0000-0002-8969-2941

Tatjana Van Der Heggen (T)

Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Evelien Snauwaert (E)

Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Pediatric Nephrology, ERKNet Center, Ghent University Hospital, Ghent, Belgium.

Jef Willems (J)

Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Siska Croubels (S)

Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Joris Delanghe (J)

Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Jan J De Waele (JJ)

Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.

Roos Colman (R)

Biostatistics Unit, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Johan Vande Walle (J)

Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Pediatric Nephrology, ERKNet Center, Ghent University Hospital, Ghent, Belgium.

Peter De Paepe (P)

Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Pieter A De Cock (PA)

Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Pharmacy, Ghent University Hospital, Ghent, Belgium.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Predictors of augmented renal clearance based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Predictors of augmented renal clearance based...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Predictors of augmented renal clearance based...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Iodo-benzoates › Acides triiodo-benzoïques › Iohexol › Predictors of augmented renal clearance based...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › Predictors of augmented renal clearance based...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic urologique › Tests de la fonction rénale › Predictors of augmented renal clearance based...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Predictors of augmented renal clearance based...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Créatinine › Predictors of augmented renal clearance based...