TRP Channels in Stroke.

Blood-brain barrier Glial activation Immune cell infiltration Neuronal death Stroke TRP channels

Journal

Neuroscience bulletin
ISSN: 1995-8218
Titre abrégé: Neurosci Bull
Pays: Singapore
ID NLM: 101256850

Informations de publication

Date de publication:
23 Nov 2023
Historique:
received: 10 07 2023
accepted: 11 09 2023
medline: 23 11 2023
pubmed: 23 11 2023
entrez: 23 11 2023
Statut: aheadofprint

Résumé

Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for mitigating brain injury after ischemic stroke. TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury. To date, many members of the TRP superfamily have been reported to contribute to ischemic brain injury, including the TRPC subfamily (1, 3, 4, 5, 6, 7), TRPV subfamily (1, 2, 3, 4) and TRPM subfamily (2, 4, 7). These TRP channels share structural similarities but have distinct channel functions and properties. Their activation during ischemic stroke can be beneficial, detrimental, or even both. In this review, we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.

Identifiants

pubmed: 37995056
doi: 10.1007/s12264-023-01151-5
pii: 10.1007/s12264-023-01151-5
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.

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Auteurs

Pengyu Zong (P)

Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. zong@uchc.edu.
Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT, 06269, USA. zong@uchc.edu.

Cindy X Li (CX)

Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA.

Jianlin Feng (J)

Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA.

Mara Cicchetti (M)

Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA.
Department of Neuroscience, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA.

Lixia Yue (L)

Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu.

Classifications MeSH