Sleep regularity and mortality: a prospective analysis in the UK Biobank.
UK Biobank
actigraphy
circadian rhythms
epidemiology
global health
mortality
none
sleep
sleep regularity
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
medline:
27
11
2023
pubmed:
23
11
2023
entrez:
23
11
2023
Statut:
epublish
Résumé
Irregular sleep-wake timing may cause circadian disruption leading to several chronic age-related diseases. We examined the relationship between sleep regularity and risk of all-cause, cardiovascular disease (CVD), and cancer mortality in 88,975 participants from the prospective UK Biobank cohort. The sleep regularity index (SRI) was calculated as the probability of an individual being in the same state (asleep or awake) at any two time points 24 hr apart, averaged over 7 days of accelerometry (range 0-100, with 100 being perfectly regular). The SRI was related to the risk of mortality in time-to-event models. The mean sample age was 62 years (standard deviation [SD], 8), 56% were women, and the median SRI was 60 (SD, 10). There were 3010 deaths during a mean follow-up of 7.1 years. Following adjustments for demographic and clinical variables, we identified a non-linear relationship between the SRI and all-cause mortality hazard ( Irregular sleep-wake patterns are associated with higher mortality risk. National Health and Medical Research Council of Australia (GTN2009264; GTN1158384), National Institute on Aging (AG062531), Alzheimer's Association (2018-AARG-591358), and the Banting Fellowship Program (#454104).
Sections du résumé
Background
UNASSIGNED
Irregular sleep-wake timing may cause circadian disruption leading to several chronic age-related diseases. We examined the relationship between sleep regularity and risk of all-cause, cardiovascular disease (CVD), and cancer mortality in 88,975 participants from the prospective UK Biobank cohort.
Methods
UNASSIGNED
The sleep regularity index (SRI) was calculated as the probability of an individual being in the same state (asleep or awake) at any two time points 24 hr apart, averaged over 7 days of accelerometry (range 0-100, with 100 being perfectly regular). The SRI was related to the risk of mortality in time-to-event models.
Results
UNASSIGNED
The mean sample age was 62 years (standard deviation [SD], 8), 56% were women, and the median SRI was 60 (SD, 10). There were 3010 deaths during a mean follow-up of 7.1 years. Following adjustments for demographic and clinical variables, we identified a non-linear relationship between the SRI and all-cause mortality hazard (
Conclusions
UNASSIGNED
Irregular sleep-wake patterns are associated with higher mortality risk.
Funding
UNASSIGNED
National Health and Medical Research Council of Australia (GTN2009264; GTN1158384), National Institute on Aging (AG062531), Alzheimer's Association (2018-AARG-591358), and the Banting Fellowship Program (#454104).
Identifiants
pubmed: 37995126
doi: 10.7554/eLife.88359
pii: 88359
pmc: PMC10666928
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG062531
Pays : United States
Organisme : Alzheimer's Association
ID : 2018-AARG-591358
Pays : United States
Organisme : NIA NIH HHS
ID : AG062531
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023, Cribb et al.
Déclaration de conflit d'intérêts
LC, RS, SY, NG, MC, AB, MP No competing interests declared
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