Surveillance of complicated mpox cases unresponsive to oral tecovirimat in Los Angeles County, 2022.
advanced HIV
drug resistance
mpox
surveillance
tecovirimat
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
received:
14
08
2023
revised:
14
11
2023
accepted:
20
11
2023
medline:
23
11
2023
pubmed:
23
11
2023
entrez:
23
11
2023
Statut:
aheadofprint
Résumé
The Los Angeles County Department of Public Health established a surveillance system to identify complicated (advanced HIV or hospitalized) mpox cases. From August 1st to November 30th, 2022, we identified 1,581 mpox cases of which 134 were complicated (8.5%). A subset of eight cases did not recover after either initiating or completing a course of oral tecovirimat. All eight patients were HIV positive and had advanced HIV (CD4 <200 cells/mm3). We identified eight distinct mutations previously associated with tecovirimat resistance in specimens collected from six patients. Ongoing surveillance of viral evolution requires close coordination between health departments and front-line providers.
Identifiants
pubmed: 37995310
pii: 7442652
doi: 10.1093/infdis/jiad517
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.