Molecular basis of opioid receptor signaling.
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
received:
28
08
2023
revised:
13
10
2023
accepted:
27
10
2023
pmc-release:
22
11
2024
medline:
27
11
2023
pubmed:
24
11
2023
entrez:
23
11
2023
Statut:
ppublish
Résumé
Opioids are used for pain management despite the side effects that contribute to the opioid crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the unresolved intricacies of opioid actions, receptor signaling cascades, and neuronal plasticity. Advancements in structural, molecular, and computational tools illuminate the dynamic interplay between opioids and opioid receptors, as well as the molecular determinants of signaling pathways, which are potentially interlinked with pharmacological responses. Here, we review the molecular basis of opioid receptor signaling with a focus on the structures of opioid receptors bound to endogenous peptides or pharmacological agents. These insights unveil specific interactions that dictate ligand selectivity and likely their distinctive pharmacological profiles. Biochemical analysis further unveils molecular features governing opioid receptor signaling. Simultaneously, the synergy between computational biology and medicinal chemistry continues to expedite the discovery of novel chemotypes with the promise of yielding more efficacious and safer opioid compounds.
Identifiants
pubmed: 37995655
pii: S0092-8674(23)01180-7
doi: 10.1016/j.cell.2023.10.029
pmc: PMC10710086
mid: NIHMS1943917
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Receptors, Opioid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5203-5219Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM143061
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests B.L.R. is a co-founder of Epiodyne and is listed by the University of North Carolina Chapel Hill Medical School as an inventor on technologies and small molecules related to opioid receptors.
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