A decade of Campylobacter and Campylobacter bacteraemias in a district general hospital and the surrounding London and South East region, England.

Campylobacter Campylobacter bacteraemia Exceedance Surveillance

Journal

The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424

Informations de publication

Date de publication:
21 Nov 2023
Historique:
received: 17 01 2023
revised: 07 11 2023
accepted: 14 11 2023
pubmed: 24 11 2023
medline: 24 11 2023
entrez: 23 11 2023
Statut: aheadofprint

Résumé

Campylobacter bacteraemia is a rare complication of the most common bacterial gastrointestinal infection but is associated with significant morbidity and mortality. There is limited data describing current trends in surveillance and antimicrobial resistance for the Campylobacter strains involved. At the Epsom and St Helier's University Hospital (ESTH), we noted a marked increase in Campylobacter bacteraemia infections in 2021. We extracted Campylobacter reports using the UK Health Security Agency's (UKHSA) Second Generation Surveillance System (laboratory reporting system) between 1st January 2012 and 31st December 2021. We reviewed patient records of patients with Campylobacter bacteraemia for details including presentation, past medical history, duration of hospital stay, and antibiotic use. Between 2012 and 2021, ESTH reported a total of 34 cases of Campylobacter bacteraemia. In 2021, the estimated incidence was 6.8 cases per 100,000 population and in the surrounding area, the incidence was 0.4 per 100,000 population. The incidence rate of Campylobacter bacteraemia in London and the South East region was significantly lower than ESTH (RR = 0.17, p < 0.0001). Campylobacter bacteraemia cases at ESTH reported a high number of co-morbidities (average number of comorbidities = 2.3) and had a duration of stay in hospital of a median of 7 days (IQR = 4-10 days). Campylobacter jejuni was the most commonly reported species for stool and blood Campylobacter in ESTH, London, and South East England. Campylobacter bacteraemia reports at ESTH were significantly (p < 0.001) higher than the surrounding London and South East region. While no common cause for the exceedance of Campylobacter bacteraemia has been identified, common risk factors for Campylobacter bacteraemia infection include underlying health conditions, being older, and male.

Sections du résumé

BACKGROUND BACKGROUND
Campylobacter bacteraemia is a rare complication of the most common bacterial gastrointestinal infection but is associated with significant morbidity and mortality. There is limited data describing current trends in surveillance and antimicrobial resistance for the Campylobacter strains involved. At the Epsom and St Helier's University Hospital (ESTH), we noted a marked increase in Campylobacter bacteraemia infections in 2021.
METHODS METHODS
We extracted Campylobacter reports using the UK Health Security Agency's (UKHSA) Second Generation Surveillance System (laboratory reporting system) between 1st January 2012 and 31st December 2021. We reviewed patient records of patients with Campylobacter bacteraemia for details including presentation, past medical history, duration of hospital stay, and antibiotic use.
RESULTS RESULTS
Between 2012 and 2021, ESTH reported a total of 34 cases of Campylobacter bacteraemia. In 2021, the estimated incidence was 6.8 cases per 100,000 population and in the surrounding area, the incidence was 0.4 per 100,000 population. The incidence rate of Campylobacter bacteraemia in London and the South East region was significantly lower than ESTH (RR = 0.17, p < 0.0001). Campylobacter bacteraemia cases at ESTH reported a high number of co-morbidities (average number of comorbidities = 2.3) and had a duration of stay in hospital of a median of 7 days (IQR = 4-10 days). Campylobacter jejuni was the most commonly reported species for stool and blood Campylobacter in ESTH, London, and South East England.
CONCLUSION CONCLUSIONS
Campylobacter bacteraemia reports at ESTH were significantly (p < 0.001) higher than the surrounding London and South East region. While no common cause for the exceedance of Campylobacter bacteraemia has been identified, common risk factors for Campylobacter bacteraemia infection include underlying health conditions, being older, and male.

Identifiants

DOI: 10.1016/j.jinf.2023.11.004 PMID: 37995801
pubmed: 37995801
pii: S0163-4453(23)00557-1
doi: 10.1016/j.jinf.2023.11.004
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors have no conflicts of interest to declare.

Auteurs

Alice Graham (A)

Field Service London and South East, UK Health Security Agency, Nobel House, London, United Kingdom.

Lois Hawkins (L)

Department of Infection, Epsom and St Heliers' University Hospitals, Carshalton, United Kingdom.

Sooria Balasegaram (S)

Field Service London and South East, UK Health Security Agency, Nobel House, London, United Kingdom.

Subha Narasimhan (S)

Department of Infection, Epsom and St Heliers' University Hospitals, Carshalton, United Kingdom.

John Wain (J)

Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom; Norwich Medical School, University of East Anglia (UEA), Norwich, United Kingdom.

John Clarke (J)

Field Service London and South East, UK Health Security Agency, Nobel House, London, United Kingdom; Department of Infection, Epsom and St Heliers' University Hospitals, Carshalton, United Kingdom; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom; Norwich Medical School, University of East Anglia (UEA), Norwich, United Kingdom.

Rohini Manuel (R)

Field Service London and South East, UK Health Security Agency, Nobel House, London, United Kingdom; Department of Infection, Epsom and St Heliers' University Hospitals, Carshalton, United Kingdom. Electronic address: Rohini.Manuel@ukhsa.gov.uk.

Classifications MeSH