The chemokines CCL5 and CXCL12 exhibit high-affinity binding to N-terminal peptides of the non-cognate receptors CXCR4 and CCR5, respectively.
CCL5
CCR5
CXCL12
CXCR4
chemokines
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
revised:
16
10
2023
received:
02
08
2023
accepted:
21
11
2023
pubmed:
24
11
2023
medline:
24
11
2023
entrez:
24
11
2023
Statut:
aheadofprint
Résumé
CC and CXC chemokines are distinct chemokine subfamilies. CC chemokines usually do not bind CXC-chemokine receptors and vice versa. CCR5 and CXCR4 receptors are activated by CCL5 and CXCL12 chemokines, respectively, and are also used as HIV-1 coreceptors. CCL5 contains one conserved binding site for a sulfated tyrosine residue, whereas CXCL12 is unique in having two additional sites for sulfated/nonsulfated tyrosine residues. In this study, N-terminal (Nt) CXCR4 peptides were found to bind CCL5 with somewhat higher affinities in comparison to those of short Nt-CCR5(8-20) peptides with the same number of sulfated tyrosine residues. Similarly, a long Nt-CCR5(1-27)(
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
Organisme : Kimmelman Center
Organisme : Clore Institute for High-Field Magnetic Resonance Imaging and Spectroscopy at the Weizmann Institute
Organisme : Leona M. and Harry B. Helmsley Charitable Trust
Informations de copyright
© 2023 Federation of European Biochemical Societies.
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