Photochemical reductive deamination of alpha-amino aryl alkyl ketones.


Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
12 Dec 2023
Historique:
medline: 24 11 2023
pubmed: 24 11 2023
entrez: 24 11 2023
Statut: epublish

Résumé

Photochemical reductive deamination of alpha-amino aryl alkyl ketones under photosensitizer-free conditions is presented. This protocol features high efficiency and selectivity. A plausible reaction pathway is proposed based on ultraviolet-visible absorption investigation, control experiments and deuterium-labelling studies. Mechanistic study reveals that the alpha-hydrogen atom of the ketone product originated from water.

Identifiants

pubmed: 37997158
doi: 10.1039/d3cc04837c
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14685-14688

Auteurs

Ji-Yuan Liang (JY)

Department of Otolaryngology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China. youquanzou@whu.edu.cn.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, Hubei 430071, China.
TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

Yi-Wen Su (YW)

Department of Otolaryngology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China. youquanzou@whu.edu.cn.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, Hubei 430071, China.
TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

You-Quan Zou (YQ)

Department of Otolaryngology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China. youquanzou@whu.edu.cn.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, Hubei 430071, China.
TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

Classifications MeSH