The Multifunctional Nature of the MicroRNA/AKT3 Regulatory Axis in Human Cancers.
AKT signaling
AKT3
cancer
circRNA
epigenetic regulation
lncRNA
microRNA
small non-coding RNAs
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 Nov 2023
09 Nov 2023
Historique:
received:
16
10
2023
revised:
06
11
2023
accepted:
07
11
2023
medline:
27
11
2023
pubmed:
24
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
Serine/threonine kinase (AKT) signaling regulates diverse cellular processes and is one of the most important aberrant cell survival mechanisms associated with tumorigenesis, metastasis, and chemoresistance. Targeting AKT has become an effective therapeutic strategy for the treatment of many cancers. AKT3 (PKBγ), the least studied isoform of the AKT family, has emerged as a major contributor to malignancy. AKT3 is frequently overexpressed in human cancers, and many regulatory oncogenic or tumor suppressor small non-coding RNAs (ncRNAs), including microRNAs (miRNAs), have recently been identified to be involved in regulating AKT3 expression. Therefore, a better understanding of regulatory miRNA/AKT3 networks may reveal novel biomarkers for the diagnosis of patients with cancer and may provide invaluable information for developing more effective therapeutic strategies. The aim of this review was to summarize current research progress in the isoform-specific functions of AKT3 in human cancers and the roles of dysregulated miRNA/AKT3 in specific types of human cancers.
Identifiants
pubmed: 37998329
pii: cells12222594
doi: 10.3390/cells12222594
pmc: PMC10670075
pii:
doi:
Substances chimiques
MicroRNAs
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Protein Isoforms
0
AKT3 protein, human
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : 426236 and 475599
Pays : Canada
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