Cancer Diagnosis through Contour Visualization of Gene Expression Leveraging Deep Learning Techniques.

accuracy cancer classification computation contour detection diagnosis loss precision recall visualization

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
15 Nov 2023
Historique:
received: 29 09 2023
revised: 30 10 2023
accepted: 04 11 2023
medline: 24 11 2023
pubmed: 24 11 2023
entrez: 24 11 2023
Statut: epublish

Résumé

Prompt diagnostics and appropriate cancer therapy necessitate the use of gene expression databases. The integration of analytical methods can enhance detection precision by capturing intricate patterns and subtle connections in the data. This study proposes a diagnostic-integrated approach combining Empirical Bayes Harmonization (EBS), Jensen-Shannon Divergence (JSD), deep learning, and contour mathematics for cancer detection using gene expression data. EBS preprocesses the gene expression data, while JSD measures the distributional differences between cancerous and non-cancerous samples, providing invaluable insights into gene expression patterns. Deep learning (DL) models are employed for automatic deep feature extraction and to discern complex patterns from the data. Contour mathematics is applied to visualize decision boundaries and regions in the high-dimensional feature space. JSD imparts significant information to the deep learning model, directing it to concentrate on pertinent features associated with cancerous samples. Contour visualization elucidates the model's decision-making process, bolstering interpretability. The amalgamation of JSD, deep learning, and contour mathematics in gene expression dataset analysis diagnostics presents a promising pathway for precise cancer detection. This method taps into the prowess of deep learning for feature extraction while employing JSD to pinpoint distributional differences and contour mathematics for visual elucidation. The outcomes underscore its potential as a formidable instrument for cancer detection, furnishing crucial insights for timely diagnostics and tailor-made treatment strategies.

Identifiants

pubmed: 37998588
pii: diagnostics13223452
doi: 10.3390/diagnostics13223452
pmc: PMC10670706
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Vinoth Kumar Venkatesan (VK)

School of Computer Science Engineering and Information Systems (SCORE), Vellore Institute of Technology, Vellore 632014, India.

Karthick Raghunath Kuppusamy Murugesan (KR)

Department of Computer Science and Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be University), Bangalore 562112, India.

Kaladevi Amarakundhi Chandrasekaran (KA)

Department of Computer Science and Engineering, Sona College of Technology, Salem 636005, India.

Mahesh Thyluru Ramakrishna (M)

Department of Computer Science and Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be University), Bangalore 562112, India.

Surbhi Bhatia Khan (SB)

Department of Data Science, School of Science Engineering and Environment, University of Salford, Manchester M5 4WT, UK.
Department of Engineering and Environment, University of Religions and Denominations, Qom 37491-13357, Iran.
Department of Electrical and Computer Engineering, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Ahlam Almusharraf (A)

Department of Business Administration, College of Business and Administration, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

Abdullah Albuali (A)

Department of Computer Science, School of Computer Science and Information Technology, King Faisal University, Hofuf 11671, Saudi Arabia.

Classifications MeSH