Nerve Growth Factor and Autoimmune Diseases.
NGF
arthritis
autoimmune thyroiditis
autoimmunity
mastocytosis
multiple sclerosis
neurotrophins
systemic lupus erythematosus
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
10 Nov 2023
10 Nov 2023
Historique:
received:
18
10
2023
revised:
06
11
2023
accepted:
08
11
2023
medline:
24
11
2023
pubmed:
24
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues. Evidence suggests that NGF is involved in the pathogenesis of numerous immune diseases including autoimmune thyroiditis, chronic arthritis, multiple sclerosis, systemic lupus erythematosus, mastocytosis, and chronic granulomatous disease. Furthermore, as NGF levels have been linked to disease severity, it could be considered an optimal early biomarker to identify therapeutic approach efficacy. In conclusion, by gaining insights into how these molecules function and which cells they interact with, future studies can devise targeted therapies to address various neurological, immunological, and other disorders more effectively. This knowledge may pave the way for innovative treatments based on NGF manipulation aimed at improving the quality of life for individuals affected by diseases involving neurotrophins.
Identifiants
pubmed: 37998739
pii: cimb45110562
doi: 10.3390/cimb45110562
pmc: PMC10670231
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
8950-8973Références
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